The Extent of Ventilator-Induced Lung Injury in Mice Partly Depends on Duration of Mechanical Ventilation
Figure 2
Respiratory parameters. Lung function is represented by the PaO2 to FiO2 ratio (PaO2/FiO2) (a) and static compliance of the respiratory system (b). The reference (REF) represents the median PaO2/FiO2 from 7 mice ventilated with LVT/PEEP for 30 minutes, that is, 442.4 mmHg (396.2 to 501.0) (a) or the combined static compliance of LVT/PEEP and HVT/ZEEP-ventilated mice at h (b). The static compliance did not differ between the two groups at h. Data are presented as scatter plot (median) of 11–15 (a) or 4–8 (b) mice per group (triangle = REF; circle = LVT; square = HVT). *Illustrates primary statistical analysis (*, **). NVC = nonventilated controls; LVT, HVT = LVT/PEEP or HVT/ZEEP ventilator settings; 5 h, 12 h = 5 or 12 hours of ventilation.
