The Extent of Ventilator-Induced Lung Injury in Mice Partly Depends on Duration of Mechanical Ventilation
Figure 3
Edema formation. (a): Edema formation is represented by wet to dry ratios of lung tissue (Wet/Dry). Data are presented as scatter plot (median) of 7-8 mice per group (triangle = NVC; circle = LVT; square = HVT). *Illustrates primary statistical analysis (*, **); #illustrates secondary statistical analysis (#). (b) In LVT/PEEP and HVT/ZEEP-ventilated mice, correlation analyses were performed between static compliance of respiratory system and wet/dry of pulmonary tissue. Linear correlations, Pearson correlation coefficients (), and values are depicted. NVC = nonventilated controls; LVT, HVT = LVT/PEEP or HVT/ZEEP ventilator settings; 5 h, 12 h = 5 or 12 hours of ventilation.