The Extent of Ventilator-Induced Lung Injury in Mice Partly Depends on Duration of Mechanical Ventilation
Figure 4
Alveolar-capillary permeability. ((a)-(b)) Alveolar-capillary permeability is represented by total protein and immunoglobulin (Ig)M levels in bronchoalveolar lavage fluid (BALF). (c) Alveolar epithelial type 1 cell injury is represented by receptor for advanced glycation end-products (RAGE) levels in BALF [18]. Data are presented as scatter plot (median) of 7-8 mice per group (triangle = NVC; circle = LVT; square = HVT). *Illustrates primary statistical analysis (*, **); #Illustrates secondary statistical analysis (#, ##). NVC = nonventilated controls; LVT, HVT = LVT/PEEP or HVT/ZEEP ventilator settings; 5 h, 12 h = 5 or 12 hours of ventilation.