Research Article

The Extent of Ventilator-Induced Lung Injury in Mice Partly Depends on Duration of Mechanical Ventilation

Figure 4

Alveolar-capillary permeability. ((a)-(b)) Alveolar-capillary permeability is represented by total protein and immunoglobulin (Ig)M levels in bronchoalveolar lavage fluid (BALF). (c) Alveolar epithelial type 1 cell injury is represented by receptor for advanced glycation end-products (RAGE) levels in BALF [18]. Data are presented as scatter plot (median) of 7-8 mice per group (triangle = NVC; circle = LVT; square = HVT). *Illustrates primary statistical analysis (* , ** ); #Illustrates secondary statistical analysis (# , ## ). NVC = nonventilated controls; LVT, HVT = LVT/PEEP or HVT/ZEEP ventilator settings; 5 h, 12 h = 5 or 12 hours of ventilation.
435236.fig.004a
(a)
435236.fig.004b
(b)
435236.fig.004c
(c)