The Extent of Ventilator-Induced Lung Injury in Mice Partly Depends on Duration of Mechanical Ventilation

Table 1

Ventilator settings and arterial blood gas analysis.

	LVT		HVT
	5 h	12 h	5 h	12 h
A
𝑉T	7.0 (6.8 to 7.2)	7.0 (6.8 to 7.6)	15.0 (14.9 to 15.4)	15.0 (14.8 to 15.2)
𝑃plat	11.0 (10.3 to 12.0)	11.0 (11.0 to 12.5)	20.0 (18.5 to 21.0)	25.5 (22.0 to 26.8)*
B
pH	7.48 (7.41 to 7.51)	7.34 (7.28 to 7.47)	7.43 (7.39 to 7.50)	7.46 (7.37 to 7.49)
PaCO2	32.3 (26.9 to 38.7)	42.4 (29.7 to 48.6)	32.9 (28.6 to 36.5)	31.2 (29.3 to 38.6)
BE	−1.6 (−2.3 to 2.7)	−2.9 (−4.7 to 1.7)	−1.9 (−4.5 to 2.4)	−2.1 (−3.3 to −0.4)
HCO3^−	23.0 (19.0 to 25.6)	22.8 (20.3 to 23.7)	21.4 (19.0 to 25.7)	21.7 (20.4 to 22.7)

LV_T, HV_T = ventilation with LV_T/PEEP or HV_T/ZEEP settings; 5 h, 12 h = 5 or 12 hours of ventilation; 𝑉_T = tidal volume in mL/kg; 𝑃_plat = plateau pressure in cmH₂O; PaCO₂ = partial pressure of arterial carbon dioxide in mmHg; BE = base excess in mmol/L; HCO₃⁻ = bicarbonate in mmol/L. Data are presented as median (IQR) of 4–8 (A) or 11–15 (B) mice per group. *Illustrates primary statistical analysis (*𝑃<0.05 versus 5 hours).