Research Article

The Extent of Ventilator-Induced Lung Injury in Mice Partly Depends on Duration of Mechanical Ventilation

Table 2

Total histopathology score.

NVC
5 h12 h5 h12 h

Score1.0 (0.0 to 2.0)1.5 (1.0 to 2.8)1.0 (0.0 to 2.5)3.0 (2.0 to 3.8)4.0 (3.0 to 4.8)**, #

NVC = nonventilated control; , = ventilation with /PEEP or /ZEEP settings; 5 h, 12 h = 5 or 12 hours of ventilation. Data are presented as median (IQR) of 6–8 mice per group. *illustrates primary statistical analysis (** versus NVC); #illustrates secondary statistical analysis (# versus 12 h ).