| | No antiplatelets N = 379 | Antiplatelets N = 272 | P value |
| Age, median (IQR) | 65.8 (53.2 to 78.3) | 75.2 (65.2 to 82.5) | <0.001 | Female gender, n (%) | 177 (46.7) | 112 (41.2) | 0.16 | BMI, Kg/m², median (IQR) | 27.4 (23 to 32.8) | 29 (24.5 to 34.5) | 0.015 | Caucasian, n (%) | 340 (89.6) | 251 (92.3) | 0.26 | Admission source, n (%) | | | | Emergency department | 205 (54.1) | 162 (69.6) | 0.17 | Medicine wards | 107 (28.2) | 69 (25.4) | 0.42 | Outpatient clinic | 55 (14.5) | 28 (10.3) | 0.11 | Postoperative | 10 (2.6) | 7 (2.6) | 0.96 | Another in-hospital ICU | 2 (0.53) | 6 (2.2) | 0.073 | Comorbidities | | | | Smoking history, n (%) | 88 (23.2) | 70 (25.8) | 0.46 | Chronic alcohol use, n (%) | 48 (12.7) | 17 (6.3) | 0.0058 | Hypertension, n (%) | 175 (46.2) | 200 (73.5) | <0.001 | Diabetes mellitus, n (%) | 113 (29.8) | 128 (47) | <0.001 | Dyslipidemia, n (%) | 101 (26.7) | 125 (46) | <0.001 | Coronary artery disease, n (%) | 58 (15.3) | 152 (55.9) | <0.001 | Cerebrovascular disease, n (%) | 37 (9.8) | 60 (22) | <0.001 | Peripheral artery disease, n (%) | 34 (9) | 63 (23.2) | <0.001 | Heart failure, n (%) | 17 (4.5) | 38 (14) | <0.001 | Atrial fibrillation, n (%) | 62 (16.4) | 66 (24.3) | 0.012 | Chronic obstructive pulmonary disease, n (%) | 59 (15.6) | 68 (25) | 0.0027 | Chronic kidney disease, n (%) | 65 (17.2) | 79 (29) | <0.001 | Stage V chronic kidney disease, n (%) | 30 (7.9) | 30 (11) | 0.18 | Active neoplasia, n (%) | 51 (13.5) | 37 (13.6) | 0.96 | Chronic anticoagulation, n (%) | 66 (17.4) | 45 (16.5) | 0.77 | Statin therapy, n (%) | 78 (20.6) | 139 (51.1) | <0.001 | Pharmacological immunosuppression, n (%) | 65 (17.2) | 38 (14) | 0.27 | Charlson score, median (IQR) | 4 (1 to 6) | 6 (5 to 8) | <0.001 | Type of antiplatelet, n (%) | | | | Aspirin | | 241 (88.6) | | Aspirin and clopidogrel | | 27 (9.9) | | Clopidogrel only | | 4 (1.5) | | Aspirin dose, mg, median (IQR) | | 81 (81-81) | | Type of infection n (%) | | | | Community acquired | 173 (45.6) | 123 (45.2) | 0.91 | Health care related/nosocomial | 206 (54.4) | 149 (54.8) | 0.91 | Source of infection, n (%) | | | | Respiratory | 139 (36.7) | 82 (30.1) | 0.083 | Intraabdominal | 73 (19.3) | 43 (15.8) | 0.26 | Urinary | 60 (15.8) | 62 (22.8) | 0.025 | Skin and soft tissue | 45 (11.9) | 43 (15.8) | 0.15 | Line related | 37 (9.8) | 15 (5.5) | 0.002 | Unknown | 17 (4.5) | 18 (6.6) | 0.23 | Other | 8 (2.1) | 9 (3.3) | 0.34 | Positive cultures | 261 (68.9) | 182 (66.9) | 0.6 |
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