|
| Reference | Study type | Population | n | Effect of diuretics |
|
| Mehta et al. (2002) [27] | Retrospective cohort | Patients in 4 teaching hospital ICUs affiliated with the University of California with nephrology consultations, medical and surgical ICU patients | 552 | Increased risk of death or nonrecovery of renal function (OR 1.77), magnified when patients who died within the first week after consultation were excluded (OR 3.12) |
|
| Uchino et al. (2004) [28] | Prospective multicenter, epidemiological study | ICU patients with the following etiologies of AKI: severe sepsis/septic shock (43.8%), major surgery (39.1%), low cardiac output 29.7%), hypovolemia (28.2%) | 1734 | No statistically significant difference in groups with or without diuretic use |
|
| Shiliday et al. (1997) [29] | Prospective, randomized, double-blind placebo-controlled trial | ICU patients at a single center | 92 | Increase in urine output with diuretics
Improvement in mortality for those who became nonoliguric but had lower APACHE II scores at baseline. No difference in mortality between those who became nonoliguric with placebo versus diuretics |
|
| Cantarovich et al. (2004) [30] | Prospective, randomized, double-blind, placebo-controlled trial | Multicenter trial, 13 ICUs, 10 nephrology wards | 338 | Increase in urine output with diuretics
No improvement in survival, renal recovery, number of dialysis sessions, or duration of need for dialysis between the two groups |
|
| Van der Voort et al. (2009) [31] | Prospective, randomized, double-blind, placebo-controlled trial | ICU patients at a single center treated with CVVH | 72 | Increase in urine output with diuretics.
No improvement in duration of renal failure or rate of renal recovery |
|
| Wu et al. (2012) [32] | Prospective, multicenter, observational study | Postsurgical ICU patients receiving hemodialysis | 572 | Higher doses of diuretics were associated with hypotension and increased mortality |
|
