Clinical Study
An Observational Study on Early Empiric versus Culture-Directed Antifungal Therapy in Critically Ill with Intra-Abdominal Sepsis
Table 1
Baseline demographics and medical conditions of patient cohort.
| | | Empiric () | Culture-directed () | value | | Empiric () | Culture-directed () | value |
| | Sociodemographics | Comorbidities | | Mean age (SD) | 64 (11) | 65 (14) | 0.806 | Median number of comorbidities (range) | 3 (0–7) | 3 (0–5) | 0.528 | | Gender, (%) | | |
0.009 | Respiratory | 4 (13) | 2 (11) | 1.000 | | Male | 20 (67) | 5 (28) | Urology | 1 (3) | 0 | 1.000 | | Female | 10 (33) | 13 (72) | Cardiovascular | 21 (70) | 13 (72) | 0.870 | | Race, (%) | | |
0.952 | Gastrointestinal | 17 (57) | 4 (22) | 0.020 | | Chinese | 22 (73) | 13 (72) | Endocrinology | 18 (60) | 11 (61) | 0.939 | | Malay | 2 (7) | 1 (6) | Haematology | 8 (27) | 2 (11) | 0.282 | | Indian | 2 (7) | 2 (11) | Liver impairment | 9 (30) | 4 (22) | 0.740 | | Others | 4 (13) | 2 (11) | Renal impairment | 11 (37) | 7 (39) | 0.878 |
| | Reason for surgery (, %) | | Gastrointestinal Obstruction | 5 (17) | 3 (17) | 1.000 | Liver transplant | 3 (10) | 0 | 0.282 | | Gastrointestinal Malignancy | 11 (37) | 3 (17) | 0.140 | Peritonitis | 1 (3) | 2 (11.1) | 0.547 | | Gastrointestinal Perforation | 12 (40) | 13 (72) | 0.031 | Pancreatitis | 1 (3) | 0 | 1.000 |
| | Severity of Illness | | Mean APACHE II Score (SD) | 22 (6) | 23 (8) | 0.806 | Mean SOFA score (SD) | 9 (5) | 9 (5) | 0.890 |
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