Clinical Study
An Observational Study on Early Empiric versus Culture-Directed Antifungal Therapy in Critically Ill with Intra-Abdominal Sepsis
Table 3
Microbiological results.
| ā | Empiric () | Culture-directed () | value |
| Number of subjects with positive fungal cultures, (%) | 16 (53) | 18 (100) | 0.003 | Number of subjects with significant fungal cultures, (%) | 12 (40) | 14 (78) | 0.011 | Presence of concomitant bacterial infection, (%) | 28 (93) | 15 (83) | 0.349 |
| Types of Candida species, (%) | C. spp. | 10 (33) | 14 (78) | 0.003 | C. albicans | 7 (23) | 8 (44) | 0.127 | C. tropicalis | 3 (10) | 4 (22) | 0.400 | C. glabrata | 4 (13) | 2 (11) | 1.000 | C. krusei | 1 (3) | 1 (6) | 1.000 | C. parapsilosis | 1 (3) | 0 | 1.000 | C. dubliniensis | 1 (3) | 0 | 1.000 |
| Location of isolated Candida, (%) | Sputum | 5 (17) | 3 (17) | 1.000 | Central venous catheter | 0 | 1 (6) | 0.375 | Urine | 8 (27) | 7 (39) | 0.376 | Blood | 3 (10) | 4 (22) | 0.400 | Abdominal wound | 3 (10) | 5 (28) | 0.132 | Intraoperative wound | 0 | 5 (28) | 0.005 | Peritoneal fluid | 6 (20) | 10 (56) | 0.011 | Drain | 2 (7) | 2 (11) | 0.624 |
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