Research Article
Mucolytics for Intubated Asthmatic Children: A National Survey of United Kingdom Paediatric Intensive Care Consultants
Table 2
Variety of methods in current practice to calculate dose of intratracheal recombinant human DNase.
| Basis for calculation | Dose |
| Variable dose based on body surface area | 2 mg/m2 |
| Variable dose based on weight | 0.2 mg/kg | 0.25 mg/kg | 0.25 mg/kg but only up to a maximum of 5 mg | 0.1 mg/kg if >10 kg or 0.25 mg if <10 kg (diluted) |
| Fixed dose but diluted to a volume based on weight | 2.5 mg diluted in saline to volume of 1 mL/kg | 2.5 mg diluted to either 10 mL or 50 mL (depends on size) |
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