Research Article
Determinants of Deescalation Failure in Critically Ill Patients with Sepsis: A Prospective Cohort Study
Table 1
Characteristics of patients.
| | Patient characteristics | |
| | APACHE II score | 24 ± 7.8 |
| | Serum procalcitonin | 3.9 (IQR 25% 1.1, 75% 18.4) |
| | Admission during working hours | 147 (37%) | | Admission after working hours | 248 (63%) |
| | Vasopressors at 72 hours | 236 (60%) |
| | Comorbid illnesses | | | Malignancy | 86 (22%) | | Metastatic cancer | 26 (7%) | | Hematologic malignancy | 35 (9%) | | Acute respiratory failure | 67 (17%) | | Chronic renal failure | 64 (16%) | | Dialysis dependent | 42 (11%) | | Cirrhosis | 62 (16%) | | Chronic diseases | 235 (59%) |
| | No microbial growth on admission cultures | 200 (51%) |
| | Source of sepsis | | | BSI | 83 (42%) | | Respiratory | 72 (37%) | | Urinary tract | 27 (14%) | | Peritonitis | 11 (5%) | | Surgical site | 10 (5%) |
| | Multidrug resistant organisms | 41 (21%) |
| | Fungal organisms | 36 (18%) |
| | Initial antimicrobial therapy appropriate | 112 (57%) |
| | ICU length of stay (days) | 6 (IQR 39) |
| | ICU mortality | 74 (18.7%) |
| | 28-day mortality | 114 (28.9%) |
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refers to chronic medical illnesses, that is, type 2 diabetes mellitus, coronary artery disease, and hypertension.
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