Determinants of Deescalation Failure in Critically Ill Patients with Sepsis: A Prospective Cohort Study

Table 3

Differences in patient characteristics by final antibiotic grouping.

	Deescalation ()	No change ()	Escalation ()	Mixed changes ()	value
SAPS II	48 ± 19.5	41 ± 19	47 ± 18.5	44 ± 23.7	0.007
Admission procalcitonin	2.3; (IQR 0.7–7.4)	7.9; (IQR 2–33.6)	4.6; (IQR 1.1–11.1)	11.1; (IQR 7–15.3)	0.007
No growth	86 (45.5%)	102 (65.3%)	12 (28.5%)	0	<0.001
Single site of sepsis	60 (31.7%)	35 (22.4%)	22 (52.3%)	3 (37.5%)	0.002
MDR organism	12 (6.3%)	22 (14.1%)	5 (11.9%)	2 (25%)	0.05
Fungal sepsis	11 (5.8%)	15 (9.6%)	8 (19%)	2 (25%)	0.019
ICU length of stay	6.5; (IQR 4.2–44)	5.5; (IQR 4–17)	5; (IQR 4–36.5)	7.5; (IQR 5–33.2)	0.003
ICU mortality	28 (14.8%)	38 (24.4%)	6 (14.3%)	2 (25%)	0.11