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Critical Care Research and Practice
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Critical Care Research and Practice
/
2017
/
Article
/
Tab 1
/
Review Article
Resurgence of Polymyxin B for MDR/XDR Gram-Negative Infections: An Overview of Current Evidence
Table 1
Susceptibility breakpoints of polymyxins for major pathogens.
Organism
Profile
Susceptible
Intermediate
Resistant
CLSI recommendations [
18
]
P. aeruginosa
MIC ≤ 2 mg/L
MIC = 4
MIC ≥ 8 mg/L
Acinetobacter
MIC ≤ 2 mg/L
—
MIC ≥ 4 mg/L
Non-Enterobacteriaceae
MIC ≤ 2 mg/L
MIC = 4
MIC ≥ 8 mg/L
BSAC Recommendations [
19
]
Pseudomonas
spp
.
#
MIC ≤ 4 mg/L
—
MIC ≥ 8 mg/L
Enterobacteriaceae
spp
.
#
MIC ≤ 4 mg/L
—
MIC ≥ 8 mg/L
For colistin and polymyxin B;
for colistin only. MIC: minimum inhibitory concentration; CLSI: Clinical and Laboratory Standards Institute; BSAC: British Society for Antimicrobial Chemotherapy.