Review Article
Resurgence of Polymyxin B for MDR/XDR Gram-Negative Infections: An Overview of Current Evidence
Table 2
Population pharmacokinetics of polymyxin B [
26].
| Parameter | Observation (range) |
| (mg hour/L) | 66.9 ± 21.6 (16.4–117) | (mg hour/L) | 29.2 ± 12.0 (6.05–60.5) | (mg/L) | 2.79 ± 0.90 (0.68–4.88) | Renal Clearance (L/hour) | 0.061 (0.018–0.377) | Urinary excretion (%) | 4.04 (0.98–17.4) |
|
|
: AUC over a day; : average steady-state plasma concentration; : AUC for unbound fraction.
|