Update in the Early Management and Reperfusion Strategies of Patients with Acute Ischemic Stroke

Table 2

Comparison of randomized clinical trials of endovascular thrombectomy in acute ischemic stroke.

RCT	Time window for intervention	Number of patients	Median NIHSS	Median ASPECTS	IV tPA (%)	TICI score 2b/3 (%)	mRS 0–2 at 90 days (%)	sICH (%)	Death rate (%)
MR CLEAN	<6 h from onset	I: 233, C: 267	I: 17, C: 18	I: 9, C: 9	I: 87.1, C: 90.6	59	I: 33, C: 19	I: 7.7, C: 6.4	I: 21, I: 22
ESCAPE	<12 h from onset	I: 165, C: 150	I: 16, C: 17	I: 9, C: 9	I: 72.7, C: 78.7	71	I: 53, C: 29	I: 3.6, C: 2.7	I: 10, C: 19
SWIFT PRIME	<6 h from onset	I: 98, C: 98	I: 17, C: 17	I: 9, C: 9	I: 100, C: 100	88	I: 60, C: 36	I: 0, C: 3.1	I: 9, C: 12
EXTEND-IA	<6 h from onset	I: 35, C: 35	I: 17, C: 13	I: NR, C: NR	I: 100, C: 100	86	I: 71, C: 40	I: 0, C: 5.7	I: 9, C: 20
REVASCAT	<8 h from onset	I: 103, C: 103	I: 17, C: 17	I: 7, C: 8	I: 68, C: 77.7	66	I: 44, C: 28	I: 1.9, C: 1.9	I: 18, C: 16
PISTE	<6 h from onset	I: 33, C: 32	I: 18, C: 14	I: 9, C: 9	I: 100, C: 100	87	I: 57, C: 35	I: 0, C: 0	I: 21, C: 13
DAWN	6–24 h from onset	I: 107, C: 99	I: 17, C: 17	I: NR, C: NR	I: 4.7, C: 13.1	84	I: 49, C: 13	I: 6, C: 3	I: 19, C: 18
DEFUSE 3	6–16 h from onset	I: 92, C: 90	I: 16, C: 16	I: 8, C: 8	I: 11, C: 9	76	I: 45, C: 17	I: 7, C: 4	I: 14, C: 26

RCT: randomized clinical trial; I: intervention group; C: control group; MR CLEAN: Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands; ESCAPE: Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion with Emphasis on Minimizing CT to Recanalization Times; SWIFT PRIME: Solitaire with the Intention for Thrombectomy as Primary Endovascular Treatment; EXTEND-IA: Extending the Time for Thrombolysis in Emergency Neurological Deficits—Intra-Arterial; REVASCAT: Randomized Trial of Revascularization with Solitaire FR Device versus Best Medical Therapy in the Treatment of Acute Stroke due to Anterior Circulation LVO Presenting within Eight Hours of Symptom Onset; PISTE: Pragmatic Ischaemic Stroke Thrombectomy Evaluation; DAWN: DWI or CTP Assessment with Clinical Mismatch in the Triage of Wake-Up and Late Presenting Strokes Undergoing Neurointervention with Trevo; DEFUSE 3: Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke; NIHSS: National Institutes of Health Stroke Scale; ASPECTS: Alberta Stroke Program Early Computed Tomography Score; IV tPA: intravenous recombinant tissue plasminogen activator; TICI: thrombolysis in cerebral infarction; d: day; mRS: modified Rankin Scale; sICH: symptomatic intracranial hemorrhage; NR: not reported.