Clinical and Developmental Immunology
Volume 2008 (2008), Article ID 305859, 12 pages
doi:10.1155/2008/305859
Research Article
Comparative Study of Regulatory T Cell Function of Human CD25+CD4+ T Cells from Thymocytes, Cord Blood, and Adult Peripheral Blood
Wakae Fujimaki,
1,2,3 Nozomu Takahashi,
1 Kei Ohnuma,
1 Masayoshi Nagatsu,
4 Hiromi Kurosawa,
4 Satoko Yoshida,
5 Nam H. Dang,
6 Takehiko Uchiyama,
2 and
Chikao Morimoto1
1Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan
2Department of Microbiology and Immunology, Tokyo Women's Medical University, Tokyo 162-8666, Japan
3Human Medical Science Division, Kagawa Nutrition University, Saitama 350-0288, Japan
4Department of Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo 162-8666, Japan
5Department of Obstetrics and Gynecology, Yoshida Clinic, Saitama 358-0054, Japan
6Department of Hematologic Malignancies, Nevada Cancer Institute, Las Vegas, NV 89135, USA
Received 13 February 2008; Revised 16 April 2008; Accepted 20 May 2008
Academic Editor: Yasunobu Yoshikai
Copyright © 2008 Wakae Fujimaki et al. This is an open access article distributed under the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- T. Takahashi, Y. Kuniyasu, M. Toda, et al., “Immunologic self-tolerance maintained by naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state,” International Immunology, vol. 10, no. 12, pp. 1969–1980, 1998. View at Publisher · View at Google Scholar
- S. Sakaguchi, “Naturally arising regulatory T cells for immunologic self-tolerance and negative control of immune responses,” Annual Review of Immunology, vol. 22, pp. 531–562, 2004. View at Publisher · View at Google Scholar · View at PubMed
- S. Sakaguchi, N. Sakaguchi, J. Shimizu, et al., “Immunologic tolerance maintained by regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance,” Immunological Reviews, vol. 182, pp. 18–32, 2001. View at Publisher · View at Google Scholar
- V. R. Aluvihare, M. Kallikourdis, and A. G. Betz, “Regulatory T cells mediate maternal tolerance to the fetus,” Nature Immunology, vol. 5, no. 3, pp. 266–271, 2004. View at Publisher · View at Google Scholar · View at PubMed
- J. Shimizu, S. Yamazaki, T. Takahashi, Y. Ishida, and S. Sakaguchi, “Stimulation of regulatory T cells through GITR breaks immunological self-tolerance,” Nature Immunology, vol. 3, no. 2, pp. 135–142, 2002. View at Publisher · View at Google Scholar · View at PubMed
- T. Takahashi, T. Tagami, S. Yamazaki, et al., “Immunologic self-tolerance maintained by regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4,” The Journal of Experimental Medicine, vol. 192, no. 2, pp. 303–309, 2000. View at Publisher · View at Google Scholar
- E. M. Shevach and G. L. Stephens, “The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity?,” Nature Reviews Immunology, vol. 6, no. 8, pp. 613–618, 2006. View at Publisher · View at Google Scholar · View at PubMed
- S. Hori, T. Nomura, and S. Sakaguchi, “Control of regulatory T cell development by the transcription factor Foxp3,” Science, vol. 299, no. 5609, pp. 1057–1061, 2003. View at Publisher · View at Google Scholar · View at PubMed
- J. D. Fontenot, M. A. Gavin, and A. Y. Rudensky, “Foxp3 programs the development and function of regulatory T cells,” Nature Immunology, vol. 4, no. 4, pp. 330–336, 2003. View at Publisher · View at Google Scholar · View at PubMed
- R. Khattri, T. Cox, S.-A. Yasayko, and F. Ramsdell, “An essential role for Scurfin in T regulatory cells,” Nature Immunology, vol. 4, no. 4, pp. 337–342, 2003. View at Publisher · View at Google Scholar · View at PubMed
- Y. Wu, M. Borde, V. Heissmeyer, et al., “FOXP3 controls regulatory T cell function through cooperation with NFAT,” Cell, vol. 126, no. 2, pp. 375–387, 2006. View at Publisher · View at Google Scholar · View at PubMed
- H. Yagi, T. Nomura, K. Nakamura, et al., “Crucial role of FOXP3 in the development and function of human regulatory T cells,” International Immunology, vol. 16, no. 11, pp. 1643–1656, 2004. View at Publisher · View at Google Scholar · View at PubMed
- S. J. Bensinger, A. Bandeira, M. S. Jordan, A. J. Caton, and T. M. Laufer, “Major histocompatibility complex class II-positive cortical epithelium mediates the selection of immunoregulatory T cells,” The Journal of Experimental Medicine, vol. 194, no. 4, pp. 427–438, 2001. View at Publisher · View at Google Scholar
- N. Watanabe, Y.-H. Wang, H. K. Lee, et al., “Hassall's corpuscles instruct dendritic cells to induce regulatory T cells in human thymus,” Nature, vol. 436, no. 7054, pp. 1181–1185, 2005. View at Publisher · View at Google Scholar · View at PubMed
- C. A. Thornton, J. W. Upham, M. E. Wikström, et al., “Functional maturation of T regulatory cells in human neonatal T cell responses to environmental antigens/allergens,” The Journal of Immunology, vol. 173, no. 5, pp. 3084–3092, 2004.
- Y. Takahata, A. Nomura, H. Takada, et al., “ T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene,” Experimental Hematology, vol. 32, no. 7, pp. 622–629, 2004. View at Publisher · View at Google Scholar · View at PubMed
- N. Seddiki, B. Santner-Nanan, S. G. Tangye, et al., “Persistence of naive regulatory T cells in adult life,” Blood, vol. 107, no. 7, pp. 2830–2838, 2006. View at Publisher · View at Google Scholar · View at PubMed
- K. Wing, A. Ekmark, H. Karlsson, A. Rudin, and E. Suri-Payer, “Characterization of human T cells in thymus, cord and adult blood,” Immunology, vol. 106, no. 2, pp. 190–199, 2002. View at Publisher · View at Google Scholar
- K. Wing, P. Larsson, K. Sandström, S. B. Lundin, E. Suri-Payer, and A. Rudin, “ regulatory T cells from human thymus and cord blood suppress antigen-specific T cell responses,” Immunology, vol. 115, no. 4, pp. 516–525, 2005. View at Publisher · View at Google Scholar · View at PubMed
- D. Valmori, A. Merlo, N. E. Souleimanian, C. S. Hesdorffer, and M. Ayyoub, “A peripheral circulating compartment of natural naive Tregs,” Journal of Clinical Investigation, vol. 115, no. 7, pp. 1953–1962, 2005. View at Publisher · View at Google Scholar · View at PubMed
- N. Takahashi, K. Imanishi, H. Nishida, and T. Uchiyama, “Evidence for immunologic immaturity of cord blood T cells: cord blood T cells are susceptible to tolerance induction to in vitro stimulation with a superantigen,” The Journal of Immunology, vol. 155, no. 11, pp. 5213–5219, 1995.
- K. Imanishi, K. Seo, H. Kato, et al., “Post-thymic maturation of migrating human thymic single-positive T cells: thymic T cells are more susceptible to anergy induction by toxic shock syndrome toxin-1 than cord blood T cells,” The Journal of Immunology, vol. 160, no. 1, pp. 112–119, 1998.
- M. B. Bradley and M. S. Cairo, “Cord blood immunology and stem cell transplantation,” Human Immunology, vol. 66, no. 5, pp. 431–446, 2005. View at Publisher · View at Google Scholar · View at PubMed
- N. Takahashi, H. Nishida, H. Kato, K. Imanishi, Y. Sakata, and T. Uchiyama, “Exanthematous disease induced by toxic shock syndrome toxin 1 in the early neonatal period,” The Lancet, vol. 351, no. 9116, pp. 1614–1619, 1998. View at Publisher · View at Google Scholar
- A. D. Hess, “Modulation of graft-versus-host disease: role of regulatory T lymphocytes,” Biology of Blood and Marrow Transplantation, vol. 12, no. 1, supplement 2, pp. 13–21, 2006. View at Publisher · View at Google Scholar · View at PubMed
- P. Hoffmann and M. Edinger, “ regulatory T cells and graft-versus-host disease,” Seminars in Hematology, vol. 43, no. 1, pp. 62–69, 2006. View at Publisher · View at Google Scholar · View at PubMed
- W. R. Godfrey, D. J. Spoden, Y. G. Ge, et al., “Cord blood -derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function,” Blood, vol. 105, no. 2, pp. 750–758, 2005. View at Publisher · View at Google Scholar · View at PubMed
- F. Fallarino, U. Grohmann, K. W. Hwang, et al., “Modulation of tryptophan catabolism by regulatory T cells,” Nature Immunology, vol. 4, no. 12, pp. 1206–1212, 2003. View at Publisher · View at Google Scholar · View at PubMed
- S. Read, V. Malmström, and F. Powrie, “Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of regulatory cells that control intestinal inflammation,” The Journal of Experimental Medicine, vol. 192, no. 2, pp. 295–302, 2000. View at Publisher · View at Google Scholar
- K. Wing, S. Lindgren, G. Kollberg, et al., “CD4 T cell activation by myelin oligodendrocyte glycoprotein is suppressed by adult but not cord blood T cells,” The European Journal of Immunology, vol. 33, no. 3, pp. 579–587, 2003. View at Publisher · View at Google Scholar · View at PubMed
- M. Miyara, Z. Amoura, C. Parizot, et al., “Global natural regulatory T cell depletion in active systemic lupus erythematosus,” The Journal of Immunology, vol. 175, no. 12, pp. 8392–8400, 2005.
- K. E. Earle, Q. Tang, X. Zhou, et al., “In vitro expanded human regulatory T cells suppress effector T cell proliferation,” Clinical Immunology, vol. 115, no. 1, pp. 3–9, 2005. View at Publisher · View at Google Scholar · View at PubMed
- Y. Peng, Y. Laouar, M. O. Li, E. A. Green, and R. A. Flavell, “TGF- regulates in vivo expansion of Foxp3-expressing regulatory T cells responsible for protection against diabetes,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 13, pp. 4572–4577, 2004. View at Publisher · View at Google Scholar · View at PubMed
- Y. M. D. Lo, E. S. F. Lo, N. Watson, et al., “Two-way cell traffic between mother and fetus: biologic and clinical implications,” Blood, vol. 88, no. 11, pp. 4390–4395, 1996.
- M. S. Pollack, D. Kirkpatrick, N. Kapoor, B. Dupont, and R. J. O'Breilly, “Identification by HLA typing of intrauterine-derived maternal T cells in four patients
with severe combined immunodeficiency,” The New England Journal of Medicine, vol. 307, no. 11, pp. 662–666, 1982.
- L. F. Thompson, R. D. O'Connor, and J. F. Bastian, “Phenotype and function of engrafted maternal T cells in patients with severe combined immunodeficiency,” The Journal of Immunology, vol. 133, no. 5, pp. 2513–2517, 1984.
- P. Rubinstein, C. Carrier, A. Scaradavou, et al., “Outcomes among 562 recipients of placental-blood transplants from unrelated donors,” The New England Journal of Medicine, vol. 339, no. 22, pp. 1565–1577, 1998. View at Publisher · View at Google Scholar · View at PubMed