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Table 4: Frequencies of comorbid diseases in patients with SIgMID. ( = not applicable).

Disease state Previously reported pediatric cases + 2 new cases percent Previously reported adults cases [8] percent Allergic rhinitis 9.8 12.6 Idiopathic angioedema 0 2.6 Idiopathic anaphylaxis 0 2.1 Asthma 18.7 24 Autoimmune disease* 3.9 12 Bronchiectasis 0 2.6 Failure to Thrive 9.8 N/A Gastrointestinal disease** 15.7 12 Malignancy 0 2.6 Meningitis 7.8 0.5 Nasal polyps 0 0.5 Other infections*** 9.8 1.6 Recurrent respiratory infections 74.5 32.5 Skin disease 11.8 4.7 Thyroid disease 0 0.5 Vasomotor rhinitis 3.9 37 Fatalities 7.8 0 Asymptomatic 3.9 3.1

thyroiditis, autoimmune anemia, autoimmune glomerulonephritis, rheumatoid arthritis, SLE.**Includes celiac disease, inflammatory bowel disease, diarrhea syndromes.***Nonrespiratory/nonmeningitis/nonskin.