Neonatal and Infantile Immune Responses to Encapsulated Bacteria and Conjugate Vaccines : Table 1

]>Neonatal and Infantile Immune Responses to Encapsulated Bacteria and Conjugate Vaccines : Table 1

Table 1: Characteristics of thymus-dependent and thymus-independent antigens


Characteristics	Thymus-dependent	Thymus-independent type 1	Thymus-independent type 2

T_H-cell activation	++	−	−
IgM-IgG switch	+, IgG1, IgG3	+/−, IgM, IgG2 (low quantities)	−, IgM
Booster response	++	−
Immune response in neonates	High (but lower than in adults)	Intermediate	Low
Development of antibody responses	At birth	3–18 m	24 m
Examples	Protein antigens	LPS	PS