Review Article
Cancer Vaccine by Fusions of Dendritic and Cancer Cells
Table 1
Asessment of the fusions vaccine.
| | Fusions | | | | |
| Tumor | Dendritic cell | Tumor | Adjuvant | Patients (n) | Clinical response | Ref. |
| Melanoma | Allogeneic | Autologous | | 16 | 1 (CR) | [113, 114] | | | | | | 1 (PR) | | | | | | | 5 (SD) | | | | | | | 9 (PD) | |
| Glioma | Autologous | Autologous | | 8 | 2 (PR) | [115] | | | | | | 1 (SD) | | | | | | | 5 (PD) | |
| Melanoma | Autologous | Autologous | | 17 | 1 (PR) | [116] | | | | | | 1 (SD) | | | | | | | 15 (PD) | |
| Melanoma | Allogeneic | Autologous | rh IL-2 | 11 | 1 (SD) | [117] | | | | | | 10 (PD) | |
| Glioma | Autologous | Autologous | rh IL-12 | 12 | 3 (PR) | [115, 118] | | | | | | 2 (MR) | | | | | | | 4 (SD) | | | | | | | 3 (PD) | |
| Breast cancer | Autologous | Autologous | rh IL-12 | 2 | 1 (SD) | [115, 118] | | | | | | 1 (PD) | |
| Gastric/Colorectal carcinoma | Autologous | Autologous | rh IL-12 | 3 | 1 (SD) | [115, 118] | | | | | | 2 (PD) | |
| Ovarian carcinoma | Autologous | Autologous | rh IL-12 | 3 | 2 (SD) | [115, 118] | | | | | | 1 (PD) | |
| Melanoma | Autologous | Autologous | rh IL-12 | 4 | 4 (PD) | [115, 118] |
| Breast cancer | Autologous | Autologous | | 10 | 2 (PR) | [17] | | | | | | 1 (SD) | | | | | | | 7 (PD) | |
| Renal cell carcinoma | Autologous | Autologous | | 13 | 5 (SD) | [17] | | | | | | 8 (PD) | |
| Renal cell carcinoma | Allogeneic | Autologous | | 20 | 2 (PR) | [106] | | | | | | 8 (SD) | | | | | | | 10 (PD) | |
| Hepatocellular carcinoma | Autologous | Autologous | | 1 | 1 (PD) | [10] |
| Renal cell carcinoma | Allogeneic | Autologous | | 10 | 1 (PR) | [107] | | | | | | 6 (SD) | | | | | | | 3 (PD) | |
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CR: complete response; PR: partial response; MR: mixed response; SD: stable disease; PD: progressive disease.
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