HLA-57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South India
Table 2
(a) Frequency distribution of HLA A alleles among HIV positive subjects with and without TB and among healthy renal donors (control sample). (b) Frequency distribution of HLA B alleles among HIV positive subjects with and without TB and among healthy renal donors (control sample). (c) Frequency distribution of HLA DR alleles among HIV positive subjects with and without TB and among healthy renal donors (control sample).
(a)
HLA A
HIV positive females
HIV positive males
Healthy renal donors
TB neg. F
TB pos. F
TB neg. M
TB pos. M
Females
Males
1
29 (33.0%)
9 (30.0%)
14 (23.7%)
15 (24.6%)
84 (22.3%)
65 (21.2%)
2
27 (30.7%)
12 (40.0%)
20 (33.9%)
19 (31.1%)
115 (30.6%)
95 (31.0%)
3
10 (11.4%)
3 (10.0%)
10 (16.9%)
7 (11.5%)
54 (14.4%)
32 (10.5%)
10
1 (1.1%)
0 (0.0%)
0 (0.0%)
0 (0.0%)
0 (0%)
0 (0%)
11
23 (26.1%)
7 (23.3%)
13 (22.0%)
17 (27.9%)
96 (25.5%)
82 (26.8%)
23
1 (1.1%)
0 (0.0%)
0 (0.0%)
1 (1.6%)
2 (0.5%)
10 (3.3%)
24
20 (22.7%)
8 (26.7%)
16 (27.1%)
20 (32.8%)
97 (25.8%)
79 (25.8%)
25
0 (0.0%)
0 (0.0%)
0 (0%)
0 (0%)
1 (0.3%)
1 (0.3%)
26
5 (5.7%)
2 (6.7%)
3 (5.1%)
5 (8.2%)
23 (6.1%)
23 (7.5%)
29
2 (2.3%)
4 (13.3%)
3 (5.1%)
3 (4.9%)
17 (4.5%)
10 (3.3%)
30
1 (1.1%)
0 (0.0%)
1 (1.7%)
2 (3.3%)
10 (2.7%)
14 (4.6%)
31
8 (9.1%)
1 (3.3%)
6 (10.2%)
1 (1.6%)
28 (7.4%)
28 (9.2%)
32
4 (4.5%)
1 (3.3%)
4 (6.8%)
3 (4.9%)
17 (4.5%)
10 (3.3%)
33
15 (17.0%)
5 (16.7%)
11 (18.6%)
11 (18.0%)
93 (24.7%)
72 (23.5%)
34
0 (0.0%)
0 (0.0%)
1 (1.7%)
0 (0.0%)
0 (0%)
1 (0.3%)
36
0 (0.0%)
0 (0.0%)
1 (1.7%)
0 (0.0%)
2 (0.5%)
5 (1.6%)
43
0 (0.0%)
0 (0.0%)
0 (0%)
0 (0%)
1 (0.3%)
0 (0%)
66
0 (0.0%)
0 (0.0%)
0 (0%)
0 (0%)
0 (0%)
2 (0.7%)
68
13 (14.8%)
6 (20.0%)
7 (11.9%)
9 (14.8%)
51 (13.6%)
32 (10.5%)
74
0 (0.0%)
0 (0.0%)
0 (0%)
0 (0%)
2 (0.5%)
5 (1.6%)
80
0 (0.0%)
0 (0.0%)
0 (0%)
0 (0%)
1 (0.3%)
0 (0%)
(b)
HIV positive females
HIV positive males
Healthy renal donors
HLA B
TB neg. F
TB pos. F
TB neg. M
TB pos. M
Females
Males
7
18 (20.5%)
5 (16.7%)
13 (22.0%)
10 (16.4%)
71 (18.9%)
48 (15.7%)
8
4 (4.5%)
4 (13.3%)
2 (3.4%)
4 (6.6%)
5 (1.3%)
13 (4.2%)
13
2 (2.3%)
1 (3.3%)
1 (1.7%)
4 (6.6%)
23 (6.1%)
28 (9.2%)
15
2 (2.3%)
1 (3.3%)
2 (3.4%)
0 (0.0%)
7 (1.9%)
13 (4.2%)
18
0 (0.0%)
1 (3.3%)
2 (3.4%)
4 (6.6%)
12 (3.2%)
12 (3.9%)
21
4 (4.5%)
2 (6.7%)
3 (5.1%)
2 (3.3%)
0 (0.0%)
4 (1.3%)
27
5 (5.7%)
1 (3.3%)
2 (3.4%)
1 (1.6%)
9 (2.4%)
12 (3.9%)
35
15 (17.0%)
8 (26.7%)
18 (30.5%)
20 (32.8%)
104 (27.7%)
75 (24.5%)
37
9 (10.2%)
3 (10.0%)
4 (6.8%)
8 (13.1%)
26 (6.9%)
26 (8.5%)
38
0 (0.0%)
0 (0.0%)
2 (3.4%)
3 (4.9%)
10 (2.7%)
8 (2.6%)
39
0 (0.0%)
1 (3.3%)
0 (0.0)%
1 (1.6%)
3 (0.8%)
8 (2.6%)
41
0 (0.0%)
0 (0.0%)
0 (0.0)%
1 (1.6%)
1 (0.3%)
4 (1.3%)
42
1 (1.1%)
0 (0.0%)
0 (0.0)%
0 (0.0%)
1 (0.3%)
3 (1.0%)
44
7 (8.0%)
1 (3.3%)
11 (18.6)%
8 (13.1%)
51 (13.6%)
51 (16.7%)
45
0 (0.0%)
0 (0.0%)
0 (0.0%)
0 (0.0%)
2 (0.5%)
2 (0.7%)
47
0 (0.0%)
0 (0.0%)
0 (0.0%)
0 (0.0%)
0 (0.0%)
2 (0.7%)
48
0 (0.0%)
0 (0.0%)
2 (3.4%)
0 (0.0%)
6 (1.6%)
3 (1.0%)
49
1 (1.1%)
1 (3.3%)
0 (0.0)%
1 (1.6%)
7 (1.9%)
3 (1.0%)
50
2 (2.3%)
0 (0.0%)
2 (3.4%)
1 (1.6%)
9 (2.4%)
7 (2.3%)
51
18 (20.5%)
8 (26.7%)
16 (27.1%)
14 (23.0%)
59 (15.7%)
34 (11.1%)
52
15 (17.0%)
0 (0.0%)
6 (10.2%)
6 (9.8%)
37 (9.8%)
36 (11.8%)
53
0 (0.0%)
1 (3.3%)
1 (1.7%)
0 (0.0%)
9 (2.4%)
10 (3.3%)
55
2 (2.3%)
1 (3.3%)
1 (1.7%)
2 (3.3%)
6 (1.6%)
5 (1.6%)
56
3 (3.4%)
0 (0.0%)
0 (0.0)%
0 (0.0%)
7 (1.9%)
3 (1.0%)
57
19 (21.6%)
2 (6.7%)
1 (1.7%)
4 (6.6%)
48 (12.8%)
29 (9.5%)
58
4 (4.5%)
1 (3.3%)
3 (5.1%)
3 (4.9%)
33 (8.8%)
25 (8.2%)
40
23 (26.1%)
10 (33.3%)
8 (13.6%)
12 (19.7%)
13 (3.5%)
13 (4.2%)
60
6 (6.8%)
1 (3.3%)
3 (5.1%)
1 (1.6%)
26 (6.9%)
14 (4.6%)
61
17 (19.3%)
9 (30.0%)
5 (8.5%)
11 (18.0%)
51 (13.6%)
38 (12.4%)
62
8 (9.1%)
0 (0.0%)
4 (6.8%)
3 (4.9%)
18 (4.8%)
15 (4.9%)
63
0 (0.0%)
0 (0.0%)
1 (1.7%)
0 (0.0%)
2 (0.5%)
4 (1.3%)
65
0 (0.0%)
0 (0.0%)
0 (0.0)%
0 (0.0%)
1 (0.3%)
0 (0.0%)
70
0 (0.0%)
0 (0.0%)
0 (0.0)%
0 (0.0%)
12 (3.2%)
7 (2.3%)
71
1 (1.1%)
0 (0.0%)
1 (1.7%)
1 (1.6%)
4 (1.1%)
11 (3.6%)
75
2 (2.3%)
1 (3.3%)
1 (1.7%)
3 (4.9%)
8 (2.1%)
6 (2.0%)
77
0 (0.0%)
0 (0.0%)
0 (0.0%)
0 (0.0%)
1 (0.3%)
0 (0.0%)
78
0 (0.0%)
0 (0.0%)
0 (0.0%)
0 (0.0%)
1 (0.3%)
1 (0.3%)
81
0 (0.0%)
0 (0.0%)
0 (0.0%)
0 (0.0%)
3 (0.8%)
4 (1.3%)
(c)
HIV positive females
HIV positive males
Healthy renal donors
HLA DR
TB neg. F
TB pos. F
TB neg. M
TB pos. M
Females
Males
1
5 (5.7%)
3 (10.0%)
6 (10.2%)
5 (8.2%)
17 (4.52%)
19 (6.21%)
3
0 (0.0%)
0 (0.0%)
1 (1.7%)
0 (0.00%)
9 (2.39%)
9 (2.94%)
4
20 (22.7%)
5 (16.7%)
17 (28.8%)
13 (21.3%)
39 (10.37%)
40 (13.07%)
7
22 (25.0%)
5 (16.7%)
8 (13.6%)
11 (18.0%)
72 (19.15%)
44 (14.38%)
8
3 (3.4%)
0 (0.0%)
1 (1.7%)
7 (11.5%)
3 (0.80%)
8 (2.61%)
9
0 (0.0%)
0 (0.0%)
1 (1.7%)
1 (1.6%)
0 (0.00%)
5 (1.63%)
10
11 (12.5%)
3 (10.0%)
9 (15.3%)
11 (18.0%)
36 (9.57%)
24 (7.84%)
11
9 (10.2%)
3 (10.0%)
6 (10.2%)
9 (14.8%)
20 (5.32%)
25 (8.17%)
12
3 (3.4%)
1 (3.3%)
4 (6.8%)
2 (3.3%)
14 (3.72%)
17 (5.56%)
13
13 (14.8%)
6 (20.0%)
12 (20.3%)
10 (16.4%)
47 (12.50%)
22 (7.19%)
14
20 (22.7%)
4 (13.3%)
11 (18.6%)
10 (16.4%)
34 (9.04%)
23 (7.52%)
15
47 (53.4%)
17 (56.7%)
26 (44.1%)
26 (42.6%)
105 (27.93%)
98 (32.03%)
16
4 (4.5%)
2 (6.7%)
1 (1.7%)
0 (0.00%)
4 (1.06%)
5 (1.63%)
17
3 (3.4%)
1 (3.3%)
3 (5.1%)
7 (11.5%)
9 (2.39%)
10 (3.27%)
18
0 (0.0%)
1 (3.3%)
0 (0.0%)
0 (0.00%)
0 (0.00%)
3 (0.98%)
*Using Chi-square test, the significance of frequency distribution of various HLA alleles was compared between males and females of HIV subjects with and with out TB as well as in healthy renal donors. The only significant observation noted was lower occurrence of TB in HLAB57 positive HIV infected women ().