HLA-B^∗57 and Gender Influence the Occurrence of Tuberculosis in HIV Infected People of South India

Table 2

(a) Frequency distribution of HLA A alleles among HIV positive subjects with and without TB and among healthy renal donors (control sample). (b) Frequency distribution of HLA B alleles among HIV positive subjects with and without TB and among healthy renal donors (control sample). (c) Frequency distribution of HLA DR alleles among HIV positive subjects with and without TB and among healthy renal donors (control sample).

(a)

HLA A	HIV positive females		HIV positive males		Healthy renal donors
	TB neg. F	TB pos. F	TB neg. M	TB pos. M	Females	Males
	𝑛=88	𝑛=30	𝑛=59	𝑛=61	𝑛=376	𝑛=306
1	29 (33.0%)	9 (30.0%)	14 (23.7%)	15 (24.6%)	84 (22.3%)	65 (21.2%)
2	27 (30.7%)	12 (40.0%)	20 (33.9%)	19 (31.1%)	115 (30.6%)	95 (31.0%)
3	10 (11.4%)	3 (10.0%)	10 (16.9%)	7 (11.5%)	54 (14.4%)	32 (10.5%)
10	1 (1.1%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0%)	0 (0%)
11	23 (26.1%)	7 (23.3%)	13 (22.0%)	17 (27.9%)	96 (25.5%)	82 (26.8%)
23	1 (1.1%)	0 (0.0%)	0 (0.0%)	1 (1.6%)	2 (0.5%)	10 (3.3%)
24	20 (22.7%)	8 (26.7%)	16 (27.1%)	20 (32.8%)	97 (25.8%)	79 (25.8%)
25	0 (0.0%)	0 (0.0%)	0 (0%)	0 (0%)	1 (0.3%)	1 (0.3%)
26	5 (5.7%)	2 (6.7%)	3 (5.1%)	5 (8.2%)	23 (6.1%)	23 (7.5%)
29	2 (2.3%)	4 (13.3%)	3 (5.1%)	3 (4.9%)	17 (4.5%)	10 (3.3%)
30	1 (1.1%)	0 (0.0%)	1 (1.7%)	2 (3.3%)	10 (2.7%)	14 (4.6%)
31	8 (9.1%)	1 (3.3%)	6 (10.2%)	1 (1.6%)	28 (7.4%)	28 (9.2%)
32	4 (4.5%)	1 (3.3%)	4 (6.8%)	3 (4.9%)	17 (4.5%)	10 (3.3%)
33	15 (17.0%)	5 (16.7%)	11 (18.6%)	11 (18.0%)	93 (24.7%)	72 (23.5%)
34	0 (0.0%)	0 (0.0%)	1 (1.7%)	0 (0.0%)	0 (0%)	1 (0.3%)
36	0 (0.0%)	0 (0.0%)	1 (1.7%)	0 (0.0%)	2 (0.5%)	5 (1.6%)
43	0 (0.0%)	0 (0.0%)	0 (0%)	0 (0%)	1 (0.3%)	0 (0%)
66	0 (0.0%)	0 (0.0%)	0 (0%)	0 (0%)	0 (0%)	2 (0.7%)
68	13 (14.8%)	6 (20.0%)	7 (11.9%)	9 (14.8%)	51 (13.6%)	32 (10.5%)
74	0 (0.0%)	0 (0.0%)	0 (0%)	0 (0%)	2 (0.5%)	5 (1.6%)
80	0 (0.0%)	0 (0.0%)	0 (0%)	0 (0%)	1 (0.3%)	0 (0%)

(b)

	HIV positive females		HIV positive males		Healthy renal donors
HLA B	TB neg. F	TB pos. F	TB neg. M	TB pos. M	Females	Males
	𝑛=88	𝑛=30	𝑛=59	𝑛=61	𝑛=376	𝑛=306
7	18 (20.5%)	5 (16.7%)	13 (22.0%)	10 (16.4%)	71 (18.9%)	48 (15.7%)
8	4 (4.5%)	4 (13.3%)	2 (3.4%)	4 (6.6%)	5 (1.3%)	13 (4.2%)
13	2 (2.3%)	1 (3.3%)	1 (1.7%)	4 (6.6%)	23 (6.1%)	28 (9.2%)
15	2 (2.3%)	1 (3.3%)	2 (3.4%)	0 (0.0%)	7 (1.9%)	13 (4.2%)
18	0 (0.0%)	1 (3.3%)	2 (3.4%)	4 (6.6%)	12 (3.2%)	12 (3.9%)
21	4 (4.5%)	2 (6.7%)	3 (5.1%)	2 (3.3%)	0 (0.0%)	4 (1.3%)
27	5 (5.7%)	1 (3.3%)	2 (3.4%)	1 (1.6%)	9 (2.4%)	12 (3.9%)
35	15 (17.0%)	8 (26.7%)	18 (30.5%)	20 (32.8%)	104 (27.7%)	75 (24.5%)
37	9 (10.2%)	3 (10.0%)	4 (6.8%)	8 (13.1%)	26 (6.9%)	26 (8.5%)
38	0 (0.0%)	0 (0.0%)	2 (3.4%)	3 (4.9%)	10 (2.7%)	8 (2.6%)
39	0 (0.0%)	1 (3.3%)	0 (0.0)%	1 (1.6%)	3 (0.8%)	8 (2.6%)
41	0 (0.0%)	0 (0.0%)	0 (0.0)%	1 (1.6%)	1 (0.3%)	4 (1.3%)
42	1 (1.1%)	0 (0.0%)	0 (0.0)%	0 (0.0%)	1 (0.3%)	3 (1.0%)
44	7 (8.0%)	1 (3.3%)	11 (18.6)%	8 (13.1%)	51 (13.6%)	51 (16.7%)
45	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2 (0.5%)	2 (0.7%)
47	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2 (0.7%)
48	0 (0.0%)	0 (0.0%)	2 (3.4%)	0 (0.0%)	6 (1.6%)	3 (1.0%)
49	1 (1.1%)	1 (3.3%)	0 (0.0)%	1 (1.6%)	7 (1.9%)	3 (1.0%)
50	2 (2.3%)	0 (0.0%)	2 (3.4%)	1 (1.6%)	9 (2.4%)	7 (2.3%)
51	18 (20.5%)	8 (26.7%)	16 (27.1%)	14 (23.0%)	59 (15.7%)	34 (11.1%)
52	15 (17.0%)	0 (0.0%)	6 (10.2%)	6 (9.8%)	37 (9.8%)	36 (11.8%)
53	0 (0.0%)	1 (3.3%)	1 (1.7%)	0 (0.0%)	9 (2.4%)	10 (3.3%)
55	2 (2.3%)	1 (3.3%)	1 (1.7%)	2 (3.3%)	6 (1.6%)	5 (1.6%)
56	3 (3.4%)	0 (0.0%)	0 (0.0)%	0 (0.0%)	7 (1.9%)	3 (1.0%)
57	19 (21.6%)	2 (6.7%)	1 (1.7%)	4 (6.6%)	48 (12.8%)	29 (9.5%)
58	4 (4.5%)	1 (3.3%)	3 (5.1%)	3 (4.9%)	33 (8.8%)	25 (8.2%)
40	23 (26.1%)	10 (33.3%)	8 (13.6%)	12 (19.7%)	13 (3.5%)	13 (4.2%)
60	6 (6.8%)	1 (3.3%)	3 (5.1%)	1 (1.6%)	26 (6.9%)	14 (4.6%)
61	17 (19.3%)	9 (30.0%)	5 (8.5%)	11 (18.0%)	51 (13.6%)	38 (12.4%)
62	8 (9.1%)	0 (0.0%)	4 (6.8%)	3 (4.9%)	18 (4.8%)	15 (4.9%)
63	0 (0.0%)	0 (0.0%)	1 (1.7%)	0 (0.0%)	2 (0.5%)	4 (1.3%)
65	0 (0.0%)	0 (0.0%)	0 (0.0)%	0 (0.0%)	1 (0.3%)	0 (0.0%)
70	0 (0.0%)	0 (0.0%)	0 (0.0)%	0 (0.0%)	12 (3.2%)	7 (2.3%)
71	1 (1.1%)	0 (0.0%)	1 (1.7%)	1 (1.6%)	4 (1.1%)	11 (3.6%)
75	2 (2.3%)	1 (3.3%)	1 (1.7%)	3 (4.9%)	8 (2.1%)	6 (2.0%)
77	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	1 (0.3%)	0 (0.0%)
78	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	1 (0.3%)	1 (0.3%)
81	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	3 (0.8%)	4 (1.3%)

(c)

	HIV positive females		HIV positive males		Healthy renal donors
HLA DR	TB neg. F	TB pos. F	TB neg. M	TB pos. M	Females	Males
	𝑛=88	𝑛=30	𝑛=59	𝑛=61	𝑛=376	𝑛=306
1	5 (5.7%)	3 (10.0%)	6 (10.2%)	5 (8.2%)	17 (4.52%)	19 (6.21%)
3	0 (0.0%)	0 (0.0%)	1 (1.7%)	0 (0.00%)	9 (2.39%)	9 (2.94%)
4	20 (22.7%)	5 (16.7%)	17 (28.8%)	13 (21.3%)	39 (10.37%)	40 (13.07%)
7	22 (25.0%)	5 (16.7%)	8 (13.6%)	11 (18.0%)	72 (19.15%)	44 (14.38%)
8	3 (3.4%)	0 (0.0%)	1 (1.7%)	7 (11.5%)	3 (0.80%)	8 (2.61%)
9	0 (0.0%)	0 (0.0%)	1 (1.7%)	1 (1.6%)	0 (0.00%)	5 (1.63%)
10	11 (12.5%)	3 (10.0%)	9 (15.3%)	11 (18.0%)	36 (9.57%)	24 (7.84%)
11	9 (10.2%)	3 (10.0%)	6 (10.2%)	9 (14.8%)	20 (5.32%)	25 (8.17%)
12	3 (3.4%)	1 (3.3%)	4 (6.8%)	2 (3.3%)	14 (3.72%)	17 (5.56%)
13	13 (14.8%)	6 (20.0%)	12 (20.3%)	10 (16.4%)	47 (12.50%)	22 (7.19%)
14	20 (22.7%)	4 (13.3%)	11 (18.6%)	10 (16.4%)	34 (9.04%)	23 (7.52%)
15	47 (53.4%)	17 (56.7%)	26 (44.1%)	26 (42.6%)	105 (27.93%)	98 (32.03%)
16	4 (4.5%)	2 (6.7%)	1 (1.7%)	0 (0.00%)	4 (1.06%)	5 (1.63%)
17	3 (3.4%)	1 (3.3%)	3 (5.1%)	7 (11.5%)	9 (2.39%)	10 (3.27%)
18	0 (0.0%)	1 (3.3%)	0 (0.0%)	0 (0.00%)	0 (0.00%)	3 (0.98%)

*Using Chi-square test, the significance of frequency distribution of various HLA alleles was compared between males and females of HIV subjects with and with out TB as well as in healthy renal donors. The only significant observation noted was lower occurrence of TB in HLAB57 positive HIV infected women (𝑃=0.0046).