Novel Prophylactic Vaccine Using a Prime-Boost Method and Hemagglutinating Virus of Japan-Envelope against Tuberculosis

Figure 2

Groups of mice were vaccinated 3 times every 3 weeks using the prime-boost method and challenged intravenously with M. tuberculosis H37Rv as described in the Materials and Methods section. Five or 10 weeks after challenge with TB, protection was measured by enumerating bacterial loads (CFU) in the lungs, liver, and spleen of the vaccinated mice.