Novel Prophylactic Vaccine Using a Prime-Boost Method and Hemagglutinating Virus of Japan-Envelope against Tuberculosis
Figure 6
Histopathological analysis of vaccinated mice 5 weeks after M. tuberculosis challenge. Representative photomicrographs of lung tissue sections harvested from the G1 naive control group, G2 (BCG alone) group, G3 group (DNA/DNA/DNA), and G4 group (BCG/DNA/DNA) are shown (5 weeks after M. tuberculosis challenge, hematoxylin and eosin staining, × 4 objective). There was much infiltration of mononuclear cells and extensive parenchymal destruction by large, poorly demarcated granuloma in the lungs from the G1 (naive control) group and G2 (BCG alone) group. In the G3 (DNA/DNA/DNA) group and G4 (BCG/DNA/DNA) group, there was less inflammation, and only a few granulomas were observed.
