|
| Systems, organs, tissues | AIRE expression negative or negligibly positive | AIRE expression moderately or strongly positive |
| Techniques | Cell types | Techniques | Cell types |
|
| Bone marrow | NB [4]
RT-PCR [18]
IHC [18] | | NB [5] | |
|
| Lymph nodes | IHC [18]
FC [20] | CD14− cells [20]
B lymphocytes [18]
T lymphocytes [18]
Monocytes [18]
Macrophages [18]
DCs (plasmacytoid) [18]
Epithelial cells [18]
Endothelial cells [18] | NB [4, 5]
isH [10]
RT-PCR [16, 18]
IHC [10, 11, 18]
IF [10]
FC [20] | Neutrophilic granulocytes [11] Lymphocytes [11]
CD14+ cells [20]
DCs (myeloid-lineage) [10, 18] |
|
| Spleen | NB [4]
RT-PCR [16, 18]
IHC [18] | | NB [5]
isH [10]
IHC [10, 11] | Neutrophilic granulocytes [11]
Lymphocytes (red-pulp) [11] |
|
| GALT | | | RT-PCR [18]
IHC [18] | |
|
| Fetal liver | | | NB [4, 5]
isH [10]
IHC [10] | |
|
| Adult liver | NB [4]
isH [10]
RT-PCR [16, 18]
WB [12]
IHC [10, 18] | | | |
|
| Peripheral blood leukocytes | NB [4]
RT-PCR [13, 16, 19]
ICC [10, 13]
FC [20] | Neutrophilic granulocytes [13]
PBMCs [16]
CD14− cells [16]
B lymphocytes [19]
T lymphocytes [20]
CD4+ T lymphocytes [13, 20]
CD8+ T lymphocytes [19, 20]
Monocytes [16, 19]
DCs (myeloid-lineage) [16] | NB [5]
RT-PCR [11, 13–15, 19, 20]
ICC [11, 13]
IF [11, 12]
FC [20] | Neutrophilic granulocytes [11]
PBMCs [11, 13, 19]
PBLs [11, 12]
B lymphocytes [20]
T lymphocytes [19, 20]
CD4+ T lymphocytes [19]
CD14+ cells [20]
Monocytes [11, 13, 14]
DCs (myeloid-lineage) [13–15, 19]
DCs (plasmacytoid) [15] |
|
| Skeletal muscle | RT-PCR [16, 18]
IHC [18] | | | |
|
| Cartilage and bone | RT-PCR [16, 18]
IHC [18] | | RT-PCR [21] | Chondrocytes [21] |
|
| Heart and blood vessels | isH [10]
RT-PCR [18]
IHC [10, 18] | | | |
|
| Respiratory system (upper and lower tract) | isH [10]
RT-PCR [16, 18]
IHC [10, 18] | | | |
|
| Gastrointestinal system (upper tract, small and large bowel, salivary glands) | RT-PCR [16, 18]
IHC [18] | | NB [4] | |
|
| Endocrine glands (parathyroid glands, thyroid, pancreas, adrenal gland) | NB [4]
isH [10]
RT-PCR [16, 18]
WB [12]
IHC [10, 18] | | NB [5] | |
|
| Genito-urinary system, placenta, mammary gland | isH [10]
RT-PCR [16, 18]
IHC [10, 18] | | NB [5] | |
|
| Skin and annexes | isH [10]
RT-PCR [16, 18]
IHC [10, 18] | | RT-PCR [22]
IF [22, 23] | Keratinocytes (epidermal and HF) [23] |
|
| Central and peripheral nervous system | RT-PCR [16, 18]
IHC [18] | | | |
|
| Eye and annexes | RT-PCR [18]
IHC [18] | | | |
|