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Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 606195, 12 pages
doi:10.1155/2012/606195
Clinical and Pathological Roles of Ro/SSA Autoantibody System
1Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
2Program in Genomics of Differentiation, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
Received 4 October 2012; Accepted 19 November 2012
Academic Editor: Dimitrios P. Bogdanos
Copyright © 2012 Ryusuke Yoshimi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- H. E. Prince and W. R. Hogrefe, “Evaluation of a line immunoblot assay for detection of antibodies recognizing extractable nuclear antigens,” Journal of Clinical Laboratory Analysis, vol. 12, no. 5, pp. 320–324, 1998.
- E. K. L. Chan and L. E. C. Andrade, “Antinuclear antibodies in Sjogren's syndrome,” Rheumatic Disease Clinics of North America, vol. 18, no. 3, pp. 551–570, 1992. View at Scopus
- C. A. von Muhlen and E. M. Tan, “Autoantibodies in the diagnosis of systemic rheumatic diseases,” Seminars in Arthritis and Rheumatism, vol. 24, no. 5, pp. 323–358, 1995. View at Scopus
- K. Yamamoto, “Pathogenesis of Sjogren's syndrome,” Autoimmunity Reviews, vol. 2, no. 1, pp. 13–18, 2003. View at Publisher · View at Google Scholar
- R. Kobayashi, S. Mii, T. Nakano, H. Harada, and H. Eto, “Neonatal lupus erythematosus in Japan: a review of the literature,” Autoimmunity Reviews, vol. 8, no. 6, pp. 462–466, 2009. View at Publisher · View at Google Scholar · View at Scopus
- J. Wenzel, R. Gerdsen, M. Uerlich, R. Bauer, T. Bieber, and I. Boehm, “Antibodies targeting extractable nuclear antigens: historical development and current knowledge,” British Journal of Dermatology, vol. 145, no. 6, pp. 859–867, 2001. View at Publisher · View at Google Scholar · View at Scopus
- C. Vitali, S. Bombardieri, R. Jonsson et al., “Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European consensus group,” Annals of the Rheumatic Diseases, vol. 61, no. 6, pp. 554–558, 2002. View at Publisher · View at Google Scholar · View at Scopus
- S. C. Shiboski, C. H. Shiboski, L. Criswell, et al., “American College of Rheumatology classification criteria for Sjogren's syndrome: a data-driven, expert consensus approach in the Sjogren's International Collaborative Clinical Alliance cohort,” Arthritis Care and Research, vol. 64, no. 4, pp. 475–487, 2012. View at Publisher · View at Google Scholar
- J. R. Anderson, K. Gray, J. S. Beck, and W. F. Kinnear, “Precipitating autoantibodies in Sjogren's disease,” The Lancet, vol. 278, no. 7200, pp. 456–460, 1961. View at Scopus
- G. Clark, M. Reichlin, and T. B. Tomasi Jr., “Characterization of a soluble cytoplasmic antigen reactive with sera from patients with systemic lupus erythmatosus,” The Journal of Immunology, vol. 102, no. 1, pp. 117–122, 1969. View at Scopus
- M. Mattioli and M. Reichlin, “Heterogeneity of RNA protein antigens reactive with sera of patients with systemic lupus erythematosus. Description of a cytoplasmic nonribosomal antigen,” Arthritis and Rheumatism, vol. 17, no. 4, pp. 421–429, 1974. View at Scopus
- M. A. Alspaugh and E. M. Tan, “Antibodies to cellular antigens in Sjogren's syndrome,” The Journal of Clinical Investigation, vol. 55, no. 5, pp. 1067–1073, 1975. View at Scopus
- M. Akizuki, R. Powers, and H. R. Holman, “A soluble acidic protein of the cell nucleus which reacts with serum from patients with systemic lupus erythematosus and Sjogren's syndrome,” The Journal of Clinical Investigation, vol. 59, no. 2, pp. 264–272, 1977. View at Scopus
- M. Alspaugh and P. Maddison, “Resolution of the identity of certain antigen-antibody systems in systemic lupus erythematosus and Sjogren's syndrome: an interlaboratory collaboration,” Arthritis and Rheumatism, vol. 22, no. 7, pp. 796–798, 1979. View at Scopus
- J. Schulte-Pelkum, M. Fritzler, and M. Mahler, “Latest update on the Ro/SS-a autoantibody system,” Autoimmunity Reviews, vol. 8, no. 7, pp. 632–637, 2009. View at Publisher · View at Google Scholar · View at Scopus
- P. Ghillani, C. André, C. Toly et al., “Clinical significance of anti-Ro52 (TRIM21) antibodies non-associated with anti-SSA 60kDa antibodies: results of a multicentric study,” Autoimmunity Reviews, vol. 10, no. 9, pp. 509–513, 2011. View at Publisher · View at Google Scholar · View at Scopus
- C. B. Mond, M. G. E. Peterson, and N. F. Rothfield, “Correlation of anti-Ro antibody with photosensitivity rash in systemic lupus erythematosus patients,” Arthritis and Rheumatism, vol. 32, no. 2, pp. 202–204, 1989. View at Scopus
- G. Boire, H. A. Menard, M. Gendron, A. Lussier, and D. Myhal, “Rheumatoid arthritis: anti-Ro antibodies define a non-HLA-DR4 associated clinicoserological cluster,” The Journal of Rheumatology, vol. 20, no. 10, pp. 1654–1660, 1993. View at Scopus
- D. P. McCauliffe, “Cutaneous diseases in adults associated with Anti-Ro/SS-A autoantibody production,” Lupus, vol. 6, no. 2, pp. 158–166, 1997. View at Scopus
- M. C. Hochberg, R. E. Boyd, and J. M. Ahearn, “Systemic lupus erythematosus: a review of clinico-laboratory features and immunogenetic markers in 150 patients with emphasis on demographic subsets,” Medicine, vol. 64, no. 5, pp. 285–295, 1985. View at Scopus
- M. V. Fukuda, S. C. Lo, C. S. de Almeida, and S. K. Shinjo, “Anti-Ro antibody and cutaneous vasculitis in systemic lupus erythematosus,” Clinical Rheumatology, vol. 28, no. 3, pp. 301–304, 2009. View at Publisher · View at Google Scholar · View at Scopus
- E. L. Alexander, F. C. Arnett Jr., T. T. Provost, and M. B. Stevens, “Sjogren's syndrome: association of anti-Ro(SS-A) antibodies with vasculitis, hematologic abnormalities, and serologic hyperreactivity,” Annals of Internal Medicine, vol. 98, no. 2, pp. 155–159, 1983. View at Scopus
- J. B. Harley, E. L. Alexander, W. B. Bias, et al., “Anti-Ro (SS-A) and anti-La (SS-B) in patients with Sjogren's syndrome,” Arthritis and Rheumatism, vol. 29, no. 2, pp. 196–206, 1986. View at Scopus
- J. K. Chung, M. K. Kim, and W. R. Wee, “Prognostic factors for the clinical severity of keratoconjunctivitis sicca in patients with Sjogren's syndrome,” British Journal of Ophthalmology, vol. 96, no. 2, pp. 240–245, 2012. View at Publisher · View at Google Scholar
- R. Cimaz, D. L. Spence, L. Hornberger, and E. D. Silverman, “Incidence and spectrum of neonatal lupus erythematosus: a prospective study of infants born to mothers with anti-ro autoantibodies,” Journal of Pediatrics, vol. 142, no. 6, pp. 678–683, 2003. View at Publisher · View at Google Scholar · View at Scopus
- E. Toker, S. Yavuz, and H. Direskeneli, “Anti-Ro/SSA and anti-La/SSB autoantibodies in the tear fluid of patients with Sjogren's syndrome,” British Journal of Ophthalmology, vol. 88, no. 3, pp. 384–387, 2004. View at Publisher · View at Google Scholar · View at Scopus
- A. A. Drosos, A. P. Andonopoulos, J. S. Costopoulos, E. D. Stavropoulos, C. S. Papadimitriou, and M. Moutsopoulos, “Sjogren's syndrome in progressive systemic sclerosis,” The Journal of Rheumatology, vol. 15, no. 6, pp. 965–968, 1988. View at Scopus
- I. Cavazzana, F. Franceschini, M. Quinzanini et al., “Anti-Ro/SSA antibodies in rheumatoid arthritis: clinical and immunologic associations,” Clinical and Experimental Rheumatology, vol. 24, no. 1, pp. 59–64, 2006. View at Scopus
- F. N. Skopouli, A. P. Andonopoulos, and H. M. Moutsopoulos, “Clinical implications of the presence of anti-Ro(SSA) antibodies in patients with rheumatoid arthritis,” Journal of Autoimmunity, vol. 1, no. 4, pp. 381–388, 1988. View at Scopus
- M. T. Hedgpeth and D. W. Boulware, “Interstitial pneumonitis in antinuclear antibody-negative systemic lupus erythematosus: a new clinical manifestation and possible association with anti-Ro (SS-A) antibodies,” Arthritis and Rheumatism, vol. 31, no. 4, pp. 545–548, 1988. View at Scopus
- T. T. Provost, R. Watson, and E. Simmons-O'Brien, “Anti-Ro(SS-A) antibody positive Sjogren's/lupus erythematosus overlap syndrome,” Lupus, vol. 6, no. 2, pp. 105–111, 1997. View at Scopus
- A. Parodi, P. Puiatti, and A. Rebora, “Serological profiles as prognostic clues for progressive systemic scleroderma: the Italian experience,” Dermatologica, vol. 183, no. 1, pp. 15–20, 1991. View at Scopus
- S. N. Breit, D. Cairns, A. Szentirmay et al., “The presence of Sjogren's syndrome is a major determinant of the pattern of interstitial lung disease in scleroderma and other connective tissue diseases,” The Journal of Rheumatology, vol. 16, no. 8, pp. 1043–1049, 1989. View at Scopus
- A. Vancsa, I. Csipo, J. Nemeth, K. Devenyi, L. Gergely, and K. Danko, “Characteristics of interstitial lung disease in SS-A positive/Jo-1 positive inflammatory myopathy patients,” Rheumatology International, vol. 29, no. 9, pp. 989–994, 2009.
- R. La Corte, A. Lo Mo Naco, A. Locaputo, F. Dolzani, and F. Trotta, “In patients with antisynthetase syndrome the occurrence of anti-Ro/SSA antibodies causes a more severe interstitial lung disease,” Autoimmunity, vol. 39, no. 3, pp. 249–253, 2006. View at Publisher · View at Google Scholar · View at Scopus
- J. P. Buyon, E. Ben-Chetrit, S. Karp et al., “Acquired congenital heart block. Pattern of maternal antibody response to biochemically defined antigens of the SSA/Ro-SSB/La system in neonatal lupus,” The Journal of Clinical Investigation, vol. 84, no. 2, pp. 627–634, 1989. View at Scopus
- A. Brucato, M. Frassi, F. Franceschini, et al., “Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: a prospective study of 100 women,” Arthritis and Rheumatism, vol. 44, no. 8, pp. 1832–1835, 1832.
- E. Jaeggi, C. Laskin, R. Hamilton, J. Kingdom, and E. Silverman, “The importance of the level of maternal Anti-Ro/SSA antibodies as a prognostic marker of the development of cardiac neonatal lupus erythematosus. A prospective study of 186 antibody-exposed fetuses and infants,” Journal of the American College of Cardiology, vol. 55, no. 24, pp. 2778–2784, 2010. View at Publisher · View at Google Scholar · View at Scopus
- A. Granito, P. Muratori, L. Muratori et al., “Antibodies to SS-A/Ro-52kD and centromere in autoimmune liver disease: a clue to diagnosis and prognosis of primary biliary cirrhosis,” Alimentary Pharmacology and Therapeutics, vol. 26, no. 6, pp. 831–838, 2007. View at Publisher · View at Google Scholar · View at Scopus
- A. J. Montano-Loza, Z. Shums, G. L. Norman, and A. J. Czaja, “Prognostic implications of antibodies to Ro/SSA and soluble liver antigen in type 1 autoimmune hepatitis,” Liver International, vol. 32, no. 1, pp. 85–92, 2012. View at Publisher · View at Google Scholar
- S. A. Rutjes, W. T. M. Vree Egberts, P. Jongen, F. Van Den Hoogen, G. J. M. Pruijn, and W. J. Van Venrooij, “Anti-Ro52 antibodies frequently co-occur with anti-Jo-1 antibodies in sera from patients with idiopathic inflammatory myopathy,” Clinical and Experimental Immunology, vol. 109, no. 1, pp. 32–40, 1997. View at Scopus
- M. Kubo, H. Ihn, Y. Asano, K. Yamane, N. Yazawa, and K. Tamaki, “Prevalence of 52-kd and 60-kd Ro/SS-A autoantibodies in Japanese patients with polymyositis/dermatomyositis,” Journal of the American Academy of Dermatology, vol. 47, no. 1, pp. 148–151, 2002. View at Publisher · View at Google Scholar · View at Scopus
- F. Franceschini, L. Cretti, M. Quinzanini, F. L. Rizzini, and R. Cattaneo, “Deforming arthropathy of the hands in systemic lupus erythematosus is associated with antibodies to SSA/Ro and to SSB/La,” Lupus, vol. 3, no. 5, pp. 419–422, 1994. View at Scopus
- B. T. Kurien, J. Newland, C. Paczkowski, K. L. Moore, and R. H. Scofield, “Association of neutropenia in systemic lupus erythematosus (SLE) with anti-Ro and binding of an immunologically cross-reactive neutrophil membrane antigen,” Clinical and Experimental Immunology, vol. 120, no. 1, pp. 209–217, 2000. View at Scopus
- M. R. Lerner, J. A. Boyle, J. A. Hardin, and J. A. Steitz, “Two novel classes of small ribonucleoproteins detected by antibodies associated with lupus erythematosus,” Science, vol. 211, no. 4480, pp. 400–402, 1981. View at Scopus
- S. L. Wolin and J. A. Steitz, “The Ro small cytoplasmic ribonucleoproteins: Identification of the antigenic protein and its binding site on the Ro RNAs,” Proceedings of the National Academy of Sciences of the United States of America, vol. 81, no. 7 I, pp. 1996–2000, 1984. View at Scopus
- E. Ben-Chetrit, B. J. Gandy, E. M. Tan, and K. F. Sullivan, “Isolation and characterization of a cDNA clone encoding the 60-kD component of the human SS-A/Ro ribonucleoprotein autoantigen,” The Journal of Clinical Investigation, vol. 83, no. 4, pp. 1284–1292, 1989. View at Scopus
- S. L. Deutscher, J. B. Harley, and J. D. Keene, “Molecular analysis of the 60-kDa human Ro ribonucleoprotein,” Proceedings of the National Academy of Sciences of the United States of America, vol. 85, no. 24, pp. 9479–9483, 1988. View at Scopus
- E. Ben-Chetrit, E. K. L. Chan, K. F. Sullivan, and E. M. Tan, “A 52-kD protein is a novel component of the SS-A/Ro antigenic particle,” Journal of Experimental Medicine, vol. 167, no. 5, pp. 1560–1571, 1988. View at Scopus
- E. K. L. Chan, J. C. Hamel, J. P. Buyon, and E. M. Tan, “Molecular definition and sequence motifs of the 52-kD component of human SS-A/Ro autoantigen,” The Journal of Clinical Investigation, vol. 87, no. 1, pp. 68–76, 1991. View at Scopus
- K. Itoh, Y. Itoh, and M. B. Frank, “Protein heterogeneity in the human Ro/SSA ribonucleoproteins. The 52- and 60-kD Ro/SSA autoantigens are encoded by separate genes,” The Journal of Clinical Investigation, vol. 87, no. 1, pp. 177–186, 1991. View at Scopus
- R. L. Slobbe, W. Pluk, W. J. Van Venrooij, and G. J. M. Pruijn, “Ro ribonucleoprotein assembly in vitro identification of RNA-protein and protein-protein interactions,” Journal of Molecular Biology, vol. 227, no. 2, pp. 361–366, 1992. View at Publisher · View at Google Scholar · View at Scopus
- B. T. Kurien, T. L. Chambers, P. Y. Thomas, M. B. Frank, and R. H. Scofield, “Autoantibody to the leucine zipper region of 52 kDa Ro/SSA binds native 60 kDa Ro/SSA: identification of a tertiary epitope with components from 60 kDA Ro/SSA and 52 kDa Ro/SSA,” Scandinavian Journal of Immunology, vol. 53, no. 3, pp. 268–276, 2001. View at Publisher · View at Google Scholar · View at Scopus
- G. Boire, M. Gendron, N. Monast, B. Bastin, and H. A. Menard, “Purification of antigenically intact Ro ribonucleoproteins; biochemical and immunological evidence that the 52-kD protein is not a Ro protein,” Clinical and Experimental Immunology, vol. 100, no. 3, pp. 489–498, 1995. View at Scopus
- A. Kelekar, M. R. Saitta, and J. D. Keene, “Molecular composition of Ro small ribonucleoprotein complexes in human cells. Intracellular localization of the 60- and 52-kD proteins,” The Journal of Clinical Investigation, vol. 93, no. 4, pp. 1637–1644, 1994. View at Scopus
- D. A. Rhodes, G. Ihrke, A. T. Reinicke et al., “The 52 000 MW Ro/SS-A autoantigen in Sjögren's syndrome/systemic lupus erythematosus (Ro52) is an interferon-γ inducible tripartite motif protein associated with membrane proximal structures,” Immunology, vol. 106, no. 2, pp. 246–256, 2002. View at Publisher · View at Google Scholar · View at Scopus
- H.J. Kong, D. E. Anderson, C. H. Lee, et al., “Cutting edge: autoantigen Ro52 is an interferon inducible E3 ligase that ubiquitinates IRF-8 and enhances cytokine expression in macrophages,” The Journal of Immunology, vol. 179, no. 1, pp. 26–30, 2007. View at Scopus
- S. D. Der, A. Zhou, B. R. G. Williams, and R. H. Silverman, “Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 26, pp. 15623–15628, 1998. View at Publisher · View at Google Scholar · View at Scopus
- L. Strandberg, A. Ambrosi, A. Espinosa et al., “Interferon-α induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies,” Journal of Clinical Immunology, vol. 28, no. 3, pp. 220–231, 2008. View at Publisher · View at Google Scholar · View at Scopus
- G. K. Geiss, M. Salvatore, T. M. Tumpey et al., “Cellular transcriptional profiling in influenza a virus-infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza,” Proceedings of the National Academy of Sciences of the United States of America, vol. 99, no. 16, pp. 10736–10741, 2002. View at Publisher · View at Google Scholar · View at Scopus
- J. M. Zimmerer, G. B. Lesinski, M. D. Radmacher, A. Ruppert, and W. E. Carson, “STAT1-dependent and STAT1-independent gene expression in murine immune cells following stimulation with interferon-alpha,” Cancer Immunology, Immunotherapy, vol. 56, no. 11, pp. 1845–1852, 2007. View at Publisher · View at Google Scholar · View at Scopus
- R. Yoshimi, T. H. Chang, H. Wang, T. Atsumi, H. C. Morse III, and K. Ozato, “Gene disruption study reveals a nonredundant role for TRIM21/Ro52 in NF-κB-dependent cytokine expression in fibroblasts,” The Journal of Immunology, vol. 182, no. 12, pp. 7527–7538, 2009. View at Publisher · View at Google Scholar · View at Scopus
- A. Espinosa, V. Dardalhon, S. Brauner et al., “Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway,” Journal of Experimental Medicine, vol. 206, no. 8, pp. 1661–1671, 2009. View at Publisher · View at Google Scholar · View at Scopus
- R. Yoshimi, Y. Ishigatsubo, and K. Ozato, “Autoantigen TRIM21/Ro52 as a possible target for treatment of systemic lupus erythematosus,” International Journal of Rheumatology, vol. 2012, Article ID 718237, 11 pages, 2012. View at Publisher · View at Google Scholar
- R. Rajsbaum, J. P. Stoye, and A. O'Garra, “Type I interferon-dependent and -independent expression of tripartite motif proteins in immune cells,” European Journal of Immunology, vol. 38, no. 3, pp. 619–630, 2008. View at Publisher · View at Google Scholar · View at Scopus
- K. Ozato, D. M. Shin, T. H. Chang, and H. C. Morse III, “TRIM family proteins and their emerging roles in innate immunity,” Nature Reviews Immunology, vol. 8, no. 11, pp. 849–860, 2008. View at Publisher · View at Google Scholar · View at Scopus
- K. Wada and T. Kamitani, “Autoantigen Ro52 is an E3 ubiquitin ligase,” Biochemical and Biophysical Research Communications, vol. 339, no. 1, pp. 415–421, 2006. View at Publisher · View at Google Scholar · View at Scopus
- A. Espinosa, W. Zhou, M. Ek et al., “The Sjögren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death,” The Journal of Immunology, vol. 176, no. 10, pp. 6277–6285, 2006. View at Scopus
- A. Sabile, A. M. Meyer, C. Wirbelauer et al., “Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein,” Molecular and Cellular Biology, vol. 26, no. 16, pp. 5994–6004, 2006. View at Publisher · View at Google Scholar · View at Scopus
- J. Y. Kim and K. Ozato, “The sequestosome 1/p62 attenuates cytokine gene expression in activated macrophages by inhibiting IFN regulatory factor 8 and TNF receptor-associated factor 6/NF-κB activity,” The Journal of Immunology, vol. 182, no. 4, pp. 2131–2140, 2009. View at Publisher · View at Google Scholar · View at Scopus
- K. Wada, M. Niida, M. Tanaka, and T. Kamitani, “Ro52-mediated monoubiquitination of IKKβ down-regulates NF-κB signalling,” Journal of Biochemistry, vol. 146, no. 6, pp. 821–832, 2009. View at Publisher · View at Google Scholar · View at Scopus
- M. Niida, M. Tanaka, and T. Kamitani, “Downregulation of active IKKβ by Ro52-mediated autophagy,” Molecular Immunology, vol. 47, no. 14, pp. 2378–2387, 2010. View at Publisher · View at Google Scholar · View at Scopus
- M. B. Frank, K. Itoh, A. Fujisaku, P. Pontarotti, M. G. Mattei, and B. R. Neas, “The mapping of the human 52-kD Ro/SSA autoantigen gene to human chromosome II, and its polymorphisms,” American Journal of Human Genetics, vol. 52, no. 1, pp. 183–191, 1993. View at Scopus
- H. Tsugu, R. Horowitz, N. Gibson, and M. B. Frank, “The location of a disease-associated polymorphism and genomic structure of the human 52-kDa Ro/SSA locus (SSA1),” Genomics, vol. 24, no. 3, pp. 541–548, 1994. View at Publisher · View at Google Scholar · View at Scopus
- B. Nakken, R. Jonsson, and A. I. Bolstad, “Polymorphisms of the Ro52 gene associated with anti-Ro 52-kd autoantibodies in patients with primary Sjogren's syndrome,” Arthritis & Rheumatism, vol. 44, no. 3, pp. 638–646, 2001.
- T. Imanishi, A. Morinobu, N. Hayashi et al., “A novel polymorphism of the SSA1 gene is associated with anti-SS-A/Ro52 autoantibody in Japanese patients with primary Sjögren's syndrome,” Clinical and Experimental Rheumatology, vol. 23, no. 4, pp. 521–524, 2005. View at Scopus
- J. P. Hendrick, S. L. Wolin, J. Rinke, M. R. Lerner, and J. A. Steitz, “Ro small cytoplasmic ribonucleoproteins are a subclass of La ribonucleoproteins: further characterization of the Ro and La small ribonucleoproteins from uninfected mammalian cells,” Molecular and Cellular Biology, vol. 1, no. 12, pp. 1138–1149, 1981. View at Scopus
- C. D. Green, K. S. Long, H. Shi, and S. L. Wolin, “Binding of the 60-kDA Ro autoantigen to Y RNAs: evidence for recognition in the major groove of a conserved helix,” RNA, vol. 4, no. 7, pp. 750–765, 1998. View at Publisher · View at Google Scholar · View at Scopus
- A. Belisova, K. Semrad, O. Mayer et al., “RNA chaperone activity of protein components of human Ro RNPs,” RNA, vol. 11, no. 7, pp. 1084–1094, 2005. View at Publisher · View at Google Scholar · View at Scopus
- S. L. Wolin and K. M. Reinisch, “The Ro 60 kDa autoantigen comes into focus: Interpreting epitope mapping experiments on the basis of structure,” Autoimmunity Reviews, vol. 5, no. 6, pp. 367–372, 2006. View at Publisher · View at Google Scholar · View at Scopus
- C. A. O'Brien and S. L. Wolin, “A possible role for the 60-kD Ro autoantigen in a discard pathway for defective 5S rRNA precursors,” Genes and Development, vol. 8, no. 23, pp. 2891–2903, 1994. View at Scopus
- X. Chen, J. D. Smith, H. Shi, D. D. Yang, R. A. Flavell, and S. L. Wolin, “The Ro autoantigen binds misfolded U2 small nuclear RNAs and assists mammalian cell survival after UV irradiation,” Current Biology, vol. 13, no. 24, pp. 2206–2211, 2003. View at Publisher · View at Google Scholar · View at Scopus
- D. Xue, H. Shi, J. D. Smith et al., “A lupus-like syndrome develops in mice lacking the Ro 60-kDa protein, a major lupus autoantigen,” Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 13, pp. 7503–7508, 2003. View at Publisher · View at Google Scholar · View at Scopus
- Y. Itoh and M. Reichlin, “Autoantibodies to the Ro/SSA antigen are conformation dependent. I: anti-60 kD antibodies are mainly directed to the native protein; anti-52 kD antibodies are mainly directed to the denatured protein,” Autoimmunity, vol. 14, no. 1, pp. 57–65, 1992. View at Scopus
- G. Boire and J. Craft, “Biochemical and immunological heterogeneity of the Ro ribonucleoprotein particles. Analysis with sera specific for the Ro(hY5) particle,” The Journal of Clinical Investigation, vol. 84, no. 1, pp. 270–279, 1989. View at Scopus
- G. Boire, F. J. Lopez-Longo, S. Lapointe, and H. A. Menard, “Sera from patients with autoimmune disease recognize conformational determinants on the 60-kd Ro/SS-A protein,” Arthritis and Rheumatism, vol. 34, no. 6, pp. 722–730, 1991. View at Scopus
- Y. Itoh, K. Itoh, M. B. Frank, and M. Reichlin, “Autoantibodies to the Ro/SSA autoantigen are conformation dependent II: antibodies to the denatured form of 52 kD Ro/SSA are a cross reacting subset of antibodies to the native 60 kD Ro/SSA molecule,” Autoimmunity, vol. 14, no. 2, pp. 89–95, 1993. View at Scopus
- T. Dörner, E. Feist, A. Wagenmann et al., “Anti-52 kDa Ro(SSA) autoantibodies in different autoimmune diseases preferentially recognize epitopes on the central region of the antigen,” The Journal of Rheumatology, vol. 23, no. 3, pp. 462–468, 1996. View at Scopus
- T. Fukuda-Kamitani and T. Kamitani, “Ubiquitination of Ro52 autoantigen,” Biochemical and Biophysical Research Communications, vol. 295, no. 4, pp. 774–778, 2002. View at Publisher · View at Google Scholar · View at Scopus
- M. T. McClain, L. D. Heinlen, G. J. Dennis, J. Roebuck, J. B. Harley, and J. A. James, “Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry,” Nature Medicine, vol. 11, no. 1, pp. 85–89, 2005. View at Publisher · View at Google Scholar · View at Scopus
- A. Doria, M. Canova, M. Tonon et al., “Infections as triggers and complications of systemic lupus erythematosus,” Autoimmunity Reviews, vol. 8, no. 1, pp. 24–28, 2008. View at Publisher · View at Google Scholar · View at Scopus
- B. D. Poole, A. K. Templeton, J. M. Guthridge, E. J. Brown, J. B. Harley, and J. A. James, “Aberrant epstein-barr viral infection in systemic lupus erythematosus,” Autoimmunity Reviews, vol. 8, no. 4, pp. 337–342, 2009. View at Publisher · View at Google Scholar · View at Scopus
- F. Topfer, T. Gordon, and J. Mccluskey, “Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A),” Proceedings of the National Academy of Sciences of the United States of America, vol. 92, no. 3, pp. 875–879, 1995. View at Publisher · View at Google Scholar · View at Scopus
- F. Furukawa, M. Kashihara-Sawami, M. B. Lyons, and D. A. Norris, “Binding of antibodies to the extractable nuclear antigens SS-A/Ro and SS-B/La is induced on the surface of human keratinocytes by ultraviolet light (UVL): implications for the pathogenesis of photosensitive cutaneous lupus,” Journal of Investigative Dermatology, vol. 94, no. 1, pp. 77–85, 1990. View at Scopus
- T. D. Golan, K. B. Elkon, A. E. Gharavi, and J. G. Krueger, “Enhanced membrane binding of autoantibodies to cultured keratinocytes of systemic lupus erythematosus patients after ultraviolet B/ultraviolet a irradiation,” The Journal of Clinical Investigation, vol. 90, no. 3, pp. 1067–1076, 1992. View at Scopus
- W. P. LeFeber, D. A. Norris, S. R. Ryan, et al., “Ultraviolet light induces binding of antibodies to selected nuclear antigens on cultured human keratinocytes,” The Journal of Clinical Investigation, vol. 74, no. 4, pp. 1545–1551, 1984. View at Scopus
- J. Saegusa, S. Kawano, M. Koshiba et al., “Oxidative stress mediates cell surface expression of SS-A/Ro antigen on keratinocytes,” Free Radical Biology and Medicine, vol. 32, no. 10, pp. 1006–1016, 2002. View at Publisher · View at Google Scholar · View at Scopus
- T. Dorner, M. Hucko, W. J. Mayet, U. Trefzer, G. R. Burmester, and F. Hiepe, “Enhanced membrane expression of the 52 kDa Ro(SS-A) and La(SS-B) antigens by human keratinocytes induced by TNFα,” Annals of the Rheumatic Diseases, vol. 54, no. 11, pp. 904–909, 1995. View at Scopus
- C. Baboonian, P. J. W. Venables, J. Booth, D. G. Williams, L. M. Roffe, and R. N. Maini, “Virus infection induces redistribution and membrane localization of the nuclear antigen La (SS-B): a possible mechanism for autoimmunity,” Clinical and Experimental Immunology, vol. 78, no. 3, pp. 454–459, 1989. View at Scopus
- F. Furukawa, M. B. Lyons, L. A. Lee, S. N. Coulter, and D. A. Norris, “Estradiol enhances binding to cultured human keratinocytes of antibodies specific for SS-A/Ro and SS-B/La. Another possible mechanism for estradiol influence of lupus erythematosus,” The Journal of Immunology, vol. 141, no. 5, pp. 1480–1488, 1988. View at Scopus
- L. A. Casciola-Rosen, G. Anhalt, and A. Rosen, “Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes,” Journal of Experimental Medicine, vol. 179, no. 4, pp. 1317–1330, 1994. View at Scopus
- J. G. Routsias and A. G. Tzioufas, “Autoimmune response and target autoantigens in Sjogren's syndrome,” European Journal of Clinical Investigation, vol. 40, no. 11, pp. 1026–1036, 2010. View at Publisher · View at Google Scholar · View at Scopus
- R. W. Wilson, T. T. Provost, and W. B. Bias, “Sjogren's syndrome. Influence of multiple HLA-D region alloantigens on clinical and serologic expression,” Arthritis and Rheumatism, vol. 27, no. 11, pp. 1245–1253, 1984. View at Scopus
- R. G. Hamilton, J. B. Harley, W. B. Bias et al., “Two Ro (SS-A) autoantibody responses in systemic lupus erythematosus: correlation of HLA-DR/DQ specificities with quantitative expression of Ro (SS-A) autoantibody,” Arthritis and Rheumatism, vol. 31, no. 4, pp. 496–505, 1988. View at Scopus
- J. E. Gottenberg, M. Busson, P. Loiseau et al., “In primary Sjögren's syndrome, HLA class II is associated exclusively with autoantibody production and spreading of the autoimmune response,” Arthritis and Rheumatism, vol. 48, no. 8, pp. 2240–2245, 2003. View at Publisher · View at Google Scholar · View at Scopus
- J. B. Harley, M. Reichlin, and F. C. Arnett Jr., “Gene interaction at HLA-DQ enhances autoantibody production in primary Sjogren's syndrome,” Science, vol. 232, no. 4754, pp. 1145–1147, 1986. View at Scopus
- J. D. Reveille, M. J. Macleod, K. Whittington, and F. C. Arnett Jr., “Specific amino acid residues in the second hypervariable region of HLA-DQA1 and DQB1 chain genes promote the Ro (SS-A)/La (SS-B) autoantibody responses,” The Journal of Immunology, vol. 146, no. 11, pp. 3871–3876, 1991. View at Scopus
- I. Peene, L. Meheus, S. De Keyser, R. Humbel, E. M. Veys, and F. De Keyser, “Anti-Ro52 reactivity is an independent and additional serum marker in connective tissue disease,” Annals of the Rheumatic Diseases, vol. 61, no. 10, pp. 929–933, 2002. View at Publisher · View at Google Scholar · View at Scopus
- D. M. Langguth, S. Morris, L. Clifford et al., “Specific testing for “isolated” anti-52 kDa SSA/Ro antibodies during standard anti-extractable nuclear antigen testing is of limited clinical value,” Journal of Clinical Pathology, vol. 60, no. 6, pp. 670–673, 2007. View at Publisher · View at Google Scholar · View at Scopus
- B. Rozman, B. Bozic, M. Kos-Golja, M. Plesivcnik-Novljan, and T. Kveder, “Immunoserological aspects of idiopathic inflammatory muscle disease,” Wiener Klinische Wochenschrift, vol. 112, no. 15-16, pp. 722–727, 2000. View at Scopus
- R. Brouwer, G. J. D. Hengstman, W. Vree Egberts et al., “Autoantibody profiles in the sera of European patients with myositis,” Annals of the Rheumatic Diseases, vol. 60, no. 2, pp. 116–123, 2001. View at Publisher · View at Google Scholar · View at Scopus
- M. Koenig, M. J. Fritzler, I. N. Targoff, Y. Troyanov, and J. L. Senécal, “Heterogeneity of autoantibodies in 100 patients with autoimmune myositis: insights into clinical features and outcomes,” Arthritis Research and Therapy, vol. 9, no. 4, article R78, 2007. View at Publisher · View at Google Scholar · View at Scopus
- V. Eyraud, O. Chazouilleres, E. Ballot, C. Corpechot, R. Poupon, and C. Johanet, “Significance of antibodies to soluble liver antigen/liver pancreas: a large French study,” Liver International, vol. 29, no. 6, pp. 857–864, 2009. View at Publisher · View at Google Scholar · View at Scopus
- F. Franceschini and I. Cavazzana, “Anti-Ro/SSA and La/SSB antibodies,” Autoimmunity, vol. 38, no. 1, pp. 55–63, 2005. View at Publisher · View at Google Scholar · View at Scopus
- P. J. Maddison, T. T. Provost, and M. Reichlin, “Serological findings in patients with 'ANA-negative' systemic lupus erythematosus,” Medicine, vol. 60, no. 2, pp. 87–94, 1981. View at Scopus
- T. T. Provost, F. C. Arnett Jr., and M. Reichlin, “Homozygous C2 deficiency, lupus erythematosus, and anti-Ro (SSA) antibodies,” Arthritis and Rheumatism, vol. 26, no. 10, pp. 1279–1282, 1983. View at Scopus
- G. Tappeiner, H. Hintner, and S. Scholz, “Systemic lupus erythematosus in hereditary deficiency of the fourth component of complement,” Journal of the American Academy of Dermatology, vol. 7, no. 1, pp. 66–79, 1982. View at Scopus
- T. T. Provost, N. Talal, J. B. Harley, M. Reichlin, and E. Alexander, “The relationship between anti-Ro (SS-A) antibody-positive Sjogren's syndrome and anti-Ro (SS-A) antibody-positive lupus erythematosus,” Archives of Dermatology, vol. 124, no. 1, pp. 63–71, 1988. View at Scopus
- J. P. Buyon, R. J. Winchester, S. G. Slade et al., “Identification of mothers at risk for congenital heart block and other neonatal lupus syndromes in their children: comparison of enzyme-linked immunosorbent assay and immunoblot for measurement of anti-SS-A/Ro and anti- SS-B/La antibodies,” Arthritis and Rheumatism, vol. 36, no. 9, pp. 1263–1273, 1993. View at Publisher · View at Google Scholar · View at Scopus
- J. P. Buyon, R. M. Clancy, and D. M. Friedman, “Cardiac manifestations of neonatal lupus erythematosus: guidelines to management, integrating clues from the bench and bedside,” Nature Clinical Practice Rheumatology, vol. 5, no. 3, pp. 139–148, 2009. View at Publisher · View at Google Scholar · View at Scopus
- M. D. Lockshin, E. Bonfa, K. Elkon, and M. L. Druzin, “Neonatal lupus risk to newborns of mothers with systemic lupus erythematosus,” Arthritis and Rheumatism, vol. 31, no. 6, pp. 697–701, 1988. View at Scopus
- S. Garcia, J. H. M. Nascimento, E. Bonfa et al., “Cellular mechanism of the conduction abnormalities induced by serum from anti-Ro/SSA-positive patients in rabbit hearts,” The Journal of Clinical Investigation, vol. 93, no. 2, pp. 718–724, 1994. View at Scopus
- O. Meyer, G. Hauptmann, and G. Tappeiner, “Genetic deficiency of C4, C2 or C1q and lupus syndromes. Association with anti-Ro (SS-A) antibodies,” Clinical and Experimental Immunology, vol. 62, no. 3, pp. 678–684, 1985. View at Scopus
- M. R. Arbuckle, M. T. McClain, M. V. Rubertone et al., “Development of autoantibodies before the clinical onset of systemic lupus erythematosus,” The New England Journal of Medicine, vol. 349, no. 16, pp. 1526–1533, 2003. View at Publisher · View at Google Scholar · View at Scopus
- C. Eriksson, H. Kokkonen, M. Johansson, G. Hallmans, G. Wadell, and S. Rantapää-Dahlqvist, “Autoantibodies predate the onset of systemic lupus erythematosus in northern Sweden,” Arthritis Research and Therapy, vol. 13, no. 1, article R30, 2011. View at Publisher · View at Google Scholar · View at Scopus
- L. J. Catoggio, R. P. Skinner, G. Smith, and P. J. Maddison, “Systemic lupus erythematosus in the elderly: clinical and serological characteristics,” The Journal of Rheumatology, vol. 11, no. 2, pp. 175–181, 1984. View at Scopus
- S. Praprotnik, B. Bozic, T. Kveder, and B. Rozman, “Fluctuation of anti-Ro/SS-A antibody levels in patients with systemic lupus erythematosus and Sjogren's syndrome: a prospective study,” Clinical and Experimental Rheumatology, vol. 17, no. 1, pp. 63–68, 1999. View at Scopus
- E. Scopelitis, J. J. Biundo, and M. A. Alspaugh, “Anti-SS-A antibody and other antinuclear antibodies in systemic lupus erythematosus,” Arthritis and Rheumatism, vol. 23, no. 3, pp. 287–293, 1980. View at Scopus
- R. H. W. M. Derksen and J. F. Meilof, “Anti-Ro/SS-A and anti-La/SS-B autoantibody levels in relation to systemic lupus erythematosus disease activity and congenital heart block: a longitudinal study comprising two consecutive pregnancies in a patient with systemic lupus erythematosus,” Arthritis and Rheumatism, vol. 35, no. 8, pp. 953–959, 1992. View at Publisher · View at Google Scholar · View at Scopus
- M. Wahren, P. Tengnér, I. Gunnarsson et al., “Ro/SS-A and La/SS-B antibody level variation in patients with Sjogren's syndrome and systemic lupus erythematosus,” Journal of Autoimmunity, vol. 11, no. 1, pp. 29–38, 1998. View at Publisher · View at Google Scholar · View at Scopus
- A. B. Hassan, I. E. Lundberg, D. Isenberg, and M. Wahren-Herlenius, “Serial analysis of Ro/SSA and La/SSB antibody levels and correlation with clinical disease activity in patients with systemic lupus erythematosus,” Scandinavian Journal of Rheumatology, vol. 31, no. 3, pp. 133–139, 2002. View at Scopus
- P. Maddison, H. Mogavero, T. T. Provost, and M. Reichlin, “The clinical significance of autoantibodies to a soluble cytoplasmic antigen in systemic lupus erythematosus and other connective tissue diseases,” The Journal of Rheumatology, vol. 6, no. 2, pp. 189–195, 1979. View at Scopus
- E. Simmons-O'Brien, S. Chen, R. Watson et al., “One hundred anti-Ro (SS-A) antibody positive patients: a 10-year follow-up,” Medicine, vol. 74, no. 3, pp. 109–130, 1995. View at Publisher · View at Google Scholar · View at Scopus
- A. Brucato, R. Cimaz, R. Caporali, V. Ramoni, and J. Buyon, “Pregnancy outcomes in patients with autoimmune diseases and anti-Ro/SSA antibodies,” Clinical Reviews in Allergy and Immunology, vol. 40, no. 1, pp. 27–41, 2011. View at Publisher · View at Google Scholar · View at Scopus
- L. Chameides, R. C. Truex, V. Vetter, W. J. Rashkind, F. M. Galioto Jr., and J. A. Noonan, “Association of maternal systemic lupus erythematosus with congenital complete heart block,” The New England Journal of Medicine, vol. 297, no. 22, pp. 1204–1207, 1977. View at Scopus
- W. L. Weston, C. Harmon, and C. Peebles, “A serological marker for neonatal lupus erythematosus,” British Journal of Dermatology, vol. 107, no. 4, pp. 377–382, 1982. View at Scopus
- L. A. Lee, W. B. Bias, F. C. Arnett Jr., et al., “Immunogenetics of the neonatal lupus syndrome,” Annals of Internal Medicine, vol. 99, no. 5, pp. 592–596, 1983. View at Scopus
- R. Claus, H. Hickstein, T. Külz et al., “Identification and management of fetuses at risk for, or affected by, congenital heart block associated with autoantibodies to SSA (Ro), SSB (La), or an HsEg5-like autoantigen,” Rheumatology International, vol. 26, no. 10, pp. 886–895, 2006. View at Publisher · View at Google Scholar · View at Scopus
- M. Fujimoto, M. Shimozuma, N. Yazawa et al., “Prevalence and clinical relevance of 52-kDa and 60-kDa Ro/SS-A autoantibodies in Japanese patients with systemic sclerosis,” Annals of the Rheumatic Diseases, vol. 56, no. 11, pp. 667–670, 1997. View at Scopus
- M. B. Frank, V. McCubbin, E. Trieu, Y. Wu, D. A. Isenberg, and I. N. Targoff, “The association of anti-Ro52 autoantibodies with myositis and scleroderma autoantibodies,” Journal of Autoimmunity, vol. 12, no. 2, pp. 137–142, 1999. View at Publisher · View at Google Scholar · View at Scopus
- I. N. Targoff, F. W. Miller, T. A. Medsger Jr., and C. V. Oddis, “Classification criteria for the idiopathic inflammatory myopathies,” Current Opinion in Rheumatology, vol. 9, no. 6, pp. 527–535, 1997. View at Scopus
- A. H. Kao, D. Lacomis, M. Lucas, N. Fertig, and C. V. Oddis, “Anti-signal recognition particle autoantibody in patients with and patients without idiopathic inflammatory myopathy,” Arthritis and Rheumatism, vol. 50, no. 1, pp. 209–215, 2004. View at Publisher · View at Google Scholar · View at Scopus
- E. Schneeberger, G. Citera, M. Heredia, and J. M. Cocco, “Clinical significance of anti-Ro antibodies in rheumatoid arthritis,” Clinical Rheumatology, vol. 27, no. 4, pp. 517–519, 2008. View at Publisher · View at Google Scholar · View at Scopus
- H. M. Moutsopoulos, H. Giotaki, P. J. Maddison, A. C. Mavridis, A. A. Drosos, and F. N. Skopouli, “Antibodies to cellular antigens in Greek patients with autoimmune rheumatic diseases: anti-Ro (SSA) antibody a possible marker of penicillamine-D intolerance,” Annals of the Rheumatic Diseases, vol. 43, no. 2, pp. 285–287, 1984. View at Scopus
- H. M. Moutsopoulos, F. N. Skopouli, A. K. Sarras, et al., “Anti-Ro(SSA) positive rheumatoid arthritis (RA): a clinicoserological group of patients with high incidence of D-penicillamine side effects,” Annals of the Rheumatic Diseases, vol. 44, no. 4, pp. 215–219, 1985. View at Scopus
- M. Tishler, B. Golbrut, Y. Shoenfeld, and M. Yaron, “Anti-Ro(SSA) antibodies in patients with rheumatoid arthritis a possible marker for gold induced side effects,” The Journal of Rheumatology, vol. 21, no. 6, pp. 1040–1042, 1994. View at Scopus
- R. Matsudaira, N. Tamura, F. Sekiya, M. Ogasawara, K. Yamanaka, and Y. Takasaki, “Anti-Ro/SSA antibodies are an independent factor associated with an insufficient response to tumor necrosis factor inhibitors in patients with rheumatoid arthritis,” The Journal of Rheumatology, vol. 38, no. 11, pp. 2346–2354, 2011.
- D. A. Norris, “Pathomechanisms of photosensitive lupus erythematosus,” Journal of Investigative Dermatology, vol. 100, no. 1, pp. 58S–68S, 1993. View at Scopus
- D. Ioannides, B. D. Golden, J. P. Buyon, and J. C. Bystryn, “Expression of SS-A/Ro and SS-B/La antigens in skin biopsy specimens of patients with photosensitive forms of lupus erythematosus,” Archives of Dermatology, vol. 136, no. 3, pp. 340–346, 2000. View at Scopus
- R. D. Sontheimer, “Photoimmunology of lupus erythematosus and dermatomyositis: a speculative review,” Photochemistry and Photobiology, vol. 63, no. 5, pp. 583–594, 1996. View at Scopus
- J. S. Deng, L. W. Bair Jr., S. Shen-Schwarz, R. Ramsey-Goldman, and T. Medsger Jr., “Localization of Ro (SS-A) antigen in the cardiac conduction system,” Arthritis and Rheumatism, vol. 30, no. 11, pp. 1232–1238, 1987. View at Scopus
- P. V. Taylor, J. S. Scott, L. M. Gerlis, E. Esscher, and O. Scott, “Maternal antibodies against fetal cardiac antigens in congenital complete heart block,” The New England Journal of Medicine, vol. 315, no. 11, pp. 667–672, 1986. View at Scopus
- C. E. Tseng and J. P. Buyon, “Neonatal lupus syndromes,” Rheumatic Disease Clinics of North America, vol. 23, no. 1, pp. 31–54, 1997. View at Publisher · View at Google Scholar · View at Scopus
- R. M. Clancy, P. J. Neufing, P. Zheng et al., “Impaired clearance of apoptotic cardiocytes is linked to anti-SSA/Ro and -SSB/La antibodies in the pathogenesis of congenital heart block,” The Journal of Clinical Investigation, vol. 116, no. 9, pp. 2413–2422, 2006. View at Publisher · View at Google Scholar · View at Scopus
- P. Briassouli, E. V. Komissarova, R. M. Clancy, and J. P. Buyon, “Role of the urokinase plasminogen activator receptor in mediating impaired efferocytosis of anti-SSA/Ro-bound apoptotic cardiocytes implications in the pathogenesis of congenital heart block,” Circulation Research, vol. 107, no. 3, pp. 374–387, 2010. View at Publisher · View at Google Scholar · View at Scopus
- P. Briassouli, D. Rifkin, R. M. Clancy, and J. P. Buyon, “Binding of anti-SSA antibodies to apoptotic fetal cardiocytes stimulates urokinase plasminogen activator (uPA)/uPA receptor-dependent activation of TGF-beta and potentiates fibrosis,” The Journal of Immunology, vol. 187, no. 10, pp. 5392–5401, 2011.
- P. E. Lazzerini, M. Acampa, F. Guideri et al., “Prolongation of the corrected QT interval in adult patients with Anti-Ro/SSA-positive connective tissue diseases,” Arthritis and Rheumatism, vol. 50, no. 4, pp. 1248–1252, 2004. View at Publisher · View at Google Scholar · View at Scopus
- J. Bourre-Tessier, A. E. Clarke, T. Huynh, et al., “Prolonged corrected QT interval in anti-Ro/SSA-positive adults with systemic lupus erythematosus,” Arthritis Care and Research, vol. 63, no. 7, pp. 1031–1037, 2011. View at Publisher · View at Google Scholar
- P. E. Lazzerini, P. L. Capecchi, M. Acampa et al., “Arrhythmogenic effects of anti-Ro/SSA antibodies on the adult heart: more than expected?” Autoimmunity Reviews, vol. 9, no. 1, pp. 40–44, 2009. View at Publisher · View at Google Scholar · View at Scopus
- P. E. Lazzerini, P. L. Capecchi, F. Guideri et al., “Comparison of frequency of complex ventricular arrhythmias in patients with positive versus negative anti-Ro/SSA and connective tissue disease,” American Journal of Cardiology, vol. 100, no. 6, pp. 1029–1034, 2007. View at Publisher · View at Google Scholar · View at Scopus
- D. L. Mallery, W. A. McEwan, S. R. Bidgood, G. J. Towers, C. M. Johnson, and L. C. James, “Antibodies mediate intracellular immunity through tripartite motif-containing 21 (TRIM21),” Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 46, pp. 19985–19990, 2010. View at Publisher · View at Google Scholar · View at Scopus
- A. Espinosa, J. Hennig, A. Ambrosi, et al., “Anti-Ro52 autoantibodies from patients with Sjogren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface,” The Journal of Biological Chemistry, vol. 286, no. 42, pp. 36478–36491, 2011.