Table 1:
Interference of ANCA pattern recognition in sera containing ANA or AMA.
Visual score
AKLIDES
Concordance
ANA homogenous
1/80 (
)
3 negative, 3 nuclear
3 negative, 3 P-ANCA
3/6 (50.0%)
1/320 (
)
2 negative, 5 nuclear
2 negative, 5 P-ANCA
2/7 (28.6%)
1/1280 (
)
4 nuclear, 3 P-ANCA
7 P-ANCA
3/7 (42.9%)
ANA speckled (
)
2 negative, 2 nuclear, 1 atypic
2 negative, 2 P-ANCA, 1 ANA-dots
3/5 (60.0%)
Atypical speckled (
)
1 negative, 3 P-ANCA
1 negative, 2 P-ANCA, 1 undetermined
3/4 (75.0%)
Centromere (
)
3 nuclear, 1 atypic
4 ANA-dots
3/4 (75.0%)
Nucleolar (
)
2 negative
2 negative
2/2 (100%)
AMA (
)
1 negative, 2 P-ANCA,
2 C-ANCA, 4 atypic, 2 nuclear
4 negative, 3 P-ANCA, 1 C-ANCA,
3 ANA-dots
4/11 (36.4%)
AMA: antimitochondrial antibodies; ANA: antinuclear antibodies; ANCA: antineutrophil cytoplasmic antibodies.
NB: a nuclear pattern in the visual score is considered concordant with ANA-dots by the AKLIDES system.