Table 2: European ancestry case-case analysis showing IRF5 haplotypes with associated functional elements and serological associations [64].

Tag SNP haplotype Promoter indel Splice variant Exon 6 indel Poly-A variant Serologic association (1) TACA In Present In Present Anti-Ro: OR = 1.50, P = 2.0 10−3   Anti-dsDNA: OR = 1.51, = 7.4 10−3 (2) TATA In Present Del Present Anti-dsDNA: OR = 1.68, = 4.9 10−5 (3) TCTA Del Present In Absent Anti-La: OR = 3.51, = 7.5 10−3 (4) GCTA Del Absent Del Present — (5) GCTG Del Absent In Absent —

The haplotypes are shown as each of the four alleles in order from 5′ to 3′ (rs2004640, rs3807306, rs10488631, rs2280714). SNP: single nucleotide polymorphism, indel: insertion/deletion, Poly-A: poly-adenylation, In: insertion, Del: deletion, OR: odds ratio, P: P value.