Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus Infection

Table 1

Studies investigating the prevalence of nonorgan specific auto-antibodies in children with chronic hepatitis C.

	𝑛	NOSAs	SMA	ANA	LKM-1	Dilution threshold of positivity	Sample/s used
Bortolotti et al. 1996 [3]	40	32.5%	17.5%	7.5%	10%	1 : 20	Single point determination
Gregorio et al. 1998 [4]	51	65%	51%	10%	8%	1 : 10	Sequential serum samples
Muratori et al. 2003 [5]	47	34%	17%	9%	15%	1 : 10	Single point determination
Gehring et al. 2006 [6]	39	8%	5%	—	2%	1 : 40	Two serum samples

Note: NOSAs, nonorgan specific autoantibodies; SMA, smooth muscle autoantibody; ANA, antinuclear antibody; LKM-1, liver kidney microsomal type-1 auto-antibody.