Table 4: Genes with different regulation in polyoma BK nephropathy.

Gene Control group BKVN group P value* C3 0.06 (0.02–0.6) 0.375 (0.03–5.27) 0.022 CCL2 0.06 (0.01–0.12) 0.22 (0.03–0.85) 0.005 CCL3 0.12 (0–0.65) 0.71 (0.16–5.89) 0.02 CCL5 3.26 (0.41–45.4) 66.9 (7.9–235) 0.003 CCR2 0 (0–6.38) 20.7 (0–158) 0.001 CCR7 0 (0–659) 35.3 (0–789) 0.017 CD19 0 (0–104) 109 (0–2440) 0.013 CD28 1.36 (0–75.1) 59.3 (0.74–448) 0.012 CD4 3.32 (0.22–15.1) 27 (6.63–209) 0.004 CD68 0.61 (0.05–1.38) 1.68 (0.97–4.79) 0.001 CD86 0.67 (0.01–16.9) 10 (0.88–32.3) 0.012 CSF1 1.42 (0.02–4.89) 5.17 (0.57–71.3) 0.049 CXCL10 0.05 (0–2.9) 1.8 (0.06–3.76) 0.015 CXCR3 0 (0–34.3) 61.2 (0–671) 0.013 EDN1 0.45 (0.14–1.32) 1.18 (0.39–8.74) 0.025 FASL 0 (0–67.2) 145.72 (25.96–409.25) 0.003 GNLY 0.36 (0.12–2.1) 4.9 (1.45–52.2) 0.001 HLADRA 0.39 (0.15–3.27) 1.55 (0.503–7.6) 0.021 HLA-DRB1 0 (0–0.39) 0.85 (0–85.6) 0.036 ICAM1 0.03 (0–0.8) 0.235 (0.06–13.1) 0.03 IFNG 2.65 (0–139) 82.1 (0–519) 0.023 IL12B 0 (0–3.83) 3.49 (0–37.6) 0.03 IL1B 0.17 (0–0.95) 1.38 (0.3–3.67) 0.002 IL2RA 0.14 (0–3.44) 3.32 (0.47–19) 0.009 IL6 0.05 (0.01–3.49) 0.72 (0.07–9.49) 0.048 IL8 0.55 (0–6.75) 14.7 (0.11–53.4) 0.004 LTA 0 (0–93.9) 68.8 (0–903) 0.036 PRF1 8.7 (0–43.3) 117 (1.4–4100) 0.007 PTPRC 1.52 (0.55–24.6) 47.6 (4.7–303) 0.001 TBX21 0 (0–15.2) 7.14 (0–383) 0.036 TGFB 0.73 (0.23–6.75) 3.42 (0.73–13) 0.025 TNF 0.61 (0.04–3.18) 8.2 (0.95–30.7) 0.002 TNFRSF18 0 (0–1.77) 1.7 (0–19.5) 0.01

Data are shown as median (minimum–maximum) of relative quantity (RQ) of gene expression calculated with regard to the reference gene (GAPDH) and calibrator. * P values calculated by Mann-Whitney U test followed by the Bonferroni adjustment.