Treatment with CB2 Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice
Figure 1
CB2 receptor is expressed in mouse penis. Immunostaining and western blotting analysis was used to detect CB2 receptor on penis from wild type and ApoE−/− mice. (a) CB2 was strongly colocalized with α-actin (smooth muscle cells marker) as well as PECAM (endothelial cell marker) in the corpus cavernosum and dorsal vessels of wild type and ApoE−/− mice. The graph shows representative images obtained from 8 different animals. (b) CB2 in the mouse penis was confirmed by western blotting which revealed a specific single band at the expected molecular weight (approximately 45 kDa). The graph shows a representative gel of western blotting showing the expression of CB2 in penis from wild type and ApoE−/− mice from 4 independent experiments.
