Treatment with CB₂ Agonist JWH-133 Reduces Histological Features Associated with Erectile Dysfunction in Hypercholesterolemic Mice

Figure 4

The treatment with JWH-133 increased NO bioavailability in the corpus cavernosum of ApoE^−/− mice. Relaxation produced by increasing cumulative concentrations of acetylcholine (a) in cavernosal strip from wild type mice and untreated and JWH-133-treated ApoE^−/− mice. ((b)-(c)) Constriction induced by cumulative concentrations of phenylephrine in the presence (c) or absence (b) of NOS inhibitor (L-NAME) in cavernosal strip. (d) Normalized curve response of phenylephrine in the presence of L-NAME by phenylephrine response at 10⁻⁶ mol/L. *𝑃<0.05, **𝑃<0.01, and ***𝑃<0.001 (two-way ANOVA followed by the Bonferroni multiple comparison test). Each point represents the mean ± SEM (𝑛=7 to 10). n.s.: nonsignificant.

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