Table 1: Genes/gene regions definitely associated with AS in Chinese population.

Chromosome location Putative genes/candidate genes SNP Reference allele Replicated or not P value 6p21 HLA-B rs13202464 G Yes <5.0 × 10−324 5q15 ERAP1 rs27434 A Yes 6.68 × 10−4 5q15 ERAP1 rs30187 T Yes 6.71 × 10−4 1p31 IL-23R rs11209026 G Yes 2.3 × 10−17 5q33 IL12B rs3212227 C Yes / 12p13 TNFRSF1A rs4149577 A Yes 8.2 × 10−4 1q21 FCRL4 rs2777963 T No / 1q23 FCGR2B rs10917661 C No / 12q24.31 ORAI1 rs7135617 T No 0.008 12q24.31 ORAI1 rs712853 C No 0.002 5q14.3 HAPLN1-EDIL3 rs4552569 C No 8.77 × 10−10 12q12 ANO6 rs17095830 G No 1.63 × 10−8 2p15 Unknown rs10865331 A Yes 1.98 × 10−8 6q21 Unknown rs13210693 A No 9.31 × 10−7

SNP: single nucleotide polymorphisms; HLA: human leukocyte antigen; ERAP1: endoplasmic reticulum aminopeptidase 1; IL-23R: interleukin-23 receptor; IL12B: interleukin-12B; TNFRSF1A: tumor necrosis factor receptor superfamily, member 1A; FCRL4: Fc receptor-like molecule 4; FCGR2B: Fc gamma receptor IIB; ORAI1: ORAI calcium release-activated calcium modulator 1; HAPLN1: hyaluronan and proteoglycan link protein 1; EDIL3: EGF-like repeats and discoidin I-like domains 3; ANO6: anoctamin 6.