Tregitope Peptides: The Active Pharmaceutical Ingredient of IVIG?

Figure 2

The broader relevance of Tregitopes is shown from left to right (counter clockwise). Tregitopes may be incorporated into protein drugs and monoclonal antibodies, to suppress antitherapeutic protein immune responses. Removing Tregitopes from autologous antigens would improve the ability of protein engineers to develop effective antibodies for target (autologous) antigens, and engineering Tregitope-depleted antibodies may improve the delivery of vaccine antigens. As described in this paper, Tregitopes may represent a new therapeutic option for autoimmune disease. In addition, Tregitopes could be used to suppress autoimmune diseases in companion animals.