Tregitope Peptides: The Active Pharmaceutical Ingredient of IVIG?

Table 1

Partial list of previously identified human IgG tregitopes.

	HLA		Location	In vitro validation		In vivo validation
	Promiscuous	EMX score*	IgG	Murine	Human	Mouse	Human
Tregitope 167	Y	30.05	Fc	Y	Y	Y	In Fc
Tregitope 289	Y	22.57	Fc	Y	Y	Y	In Fc
Tregitope 084	N	14.07	Fab	(N/A)	Y	—	**
Tregitope 009	N	14.09	Fab	(N/A)	Y	—	**
Tregitope 029B	N	16.38	Fab	(N/A)	Y	Y	Y
Tregitope 134	N	2.70	Fab	(N/A)	Y	Y	—

∗EMX Score: EpiMatrix-predicted MHC binding promiscuity; correlates with T-cell response.
N/A: no murine homolog.
∗∗Other data, not able to disclose.
In Fc: fc Fusion proteins have both Tregitope 167 and 289 present. See D. W. Scott publications.