Comparative and Functional Genomics publishes original research and reviews dealing with the post-sequencing phases of genome analysis. The journal provides a broad forum, covering studies of complex and model organisms. Research exploiting model organisms with fully sequenced genomes to understand gene function in more complex organisms are also included. Papers presenting bioinformatic and computational tools for the study of gene and genome organization are welcomed, in addition to articles covering the application of functional genomics in an industrial context, such as pharmacogenomics and genomics-based drug target identification methods.