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Table 4: ABC system genes absent in at least one species when compared to B. melitensis.

Number Family Subfamily Substrate/ Function Type B. melitensis B. abortus B. suis B. ovis B. canis IM BMEI1851 5 CCM Possibly heme export IM BMEI1852 ABC BMEI1853 6 CDI Involved in cell division IM BMEI0073, ftsX ABC BMEI0072, ftsE 7 CLS O antigen export system ABC BMEI1416, rfbB IM BMEI1415, rfbD 13 DPL PRT Proteases, lipase, S-layer protein export OMP BMEI1029 14 DPL CHV Beta-(12) glucan export IM-ABC BMEI0984 16 DPL HMT Involved in mitochondrial export systems IM-ABC BMEI1743 IM-ABC BMEI1742 22 FAE Fatty acid export IM-ABC BMEII0976 CYTP BMEI1040 31 ISB (ABCX) Iron/sulphur centre biogenesis CYTP BMEI1042 ABC BMEI1041 ABC BMEI0964 36 MKL Involved in toluene tolerance IM BMEI0965, ttg2B SS BMEI0963, ttg2C IM BMEII0087 IM BMEI0361 60 o228 Unknown MFP BMEI0359 ABC BMEI0360 IM BruAb10085 61 o228 Unknown MFP BCAN_A1712 ABC BruAb10084 62 o228 Unknown MFP BOV_1617 IM-ABC BCAN_A0087

Excludes ABC systems involved in import; : gene absent in the Brucella species; +: gene present in the Brucella species; : pseudogene present in the Brucella species; Number: refers to ABC system number in the full inventories/alignments of Brucella ABC systems