Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice

<table>Age-related locomotor activity (“open field” test) in PARP-1<sup>−/−</sup> and PARP-1<sup>+/+</sup> mice. PARP-1<sup>−/−</sup> and PARP-1<sup>+/+</sup> mice were tested for their behavior by “open field” at the indicated age. The vertical axis represents the number of crossed squares at indicated age. Student’s <i>t</i> test was performed to analyze the statistical significance of the results.</table>

Current Gerontology and Geriatrics Research

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Figure 3: Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice 