Research Article
Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice
Table 4
Tumor site and type in PARP-1−/− and PARP-1+/+ mice.
| | Tumor localization and type | PARP-1+/+ | PARP-1−/− | | | Number of
tumor-bearing mice (%) | Survival, days | Number of
tumor-bearing mice (%) | Survival, days |
| | Uterus | Sarcoma | 37 (36%) | 713 ± 21.0 | 28 (38%) | 659 ± 22.9 | | Adenocarcinoma | 5 (5%) | 799 ± 41.2 | 5 (7%) | 709 ± 33.5 | | Hemangioma | 19 (18%) | 761 ± 29.9 | 1(1%)*** | 679 | | Hemangioendothelioma | 3 (3%) | 635 | 2 (3%) | 664 | | Polyp | 8 (8%) | 718 ± 65.6 | 2 (3%) | 601 | | Ovary |
Adenocarcinoma | 1 (1%) | 961 | — | | |
Granulesa-theca cell tumor | 12 (12%) | 692 ± 52.0 | 1 (1%)** | 734 | | Hemangioma | 5 (5%) | 798 ± 71.8 | 6 (8%) | 668 ± 55.1 | | Cystadenoma | 2 (2%) | 878 ± 43.8 | 1 (1%) | 534 | | Mammary gland | Adenocarcinoma | 3 (3%) | 748 ± 163.4 | 4 (6%) | 480 ± 26.9 | | Lung | Adenocarcinoma | 4 (4%) | 596 ± 54.8 | 7 (10%) | 480 ± 26.9 | | Adenoma | 8 (8%) | 702 ± 72.5 | 4 (6%) | 749 ± 12.7 | | Liver | Hepatocellular carcinoma | 3 (3%) | 810 ± 20.6 | 6 (8%) | 664 ± 21.4*** | | Hemangioendothelioma | — | | 2 (3%) | 630 ± 35.6 | | Haemangioma | 3 (3%) | 923 ± 53.8 | 2 (3%) | 628 | | Haematopoietic
system | Malignant lymphoma | 5
(5%) | 711 ± 37.1 | 6
(8%) | 593 ± 40.1* | | Thymoma | — | — | 1 (1%) | 208 | | Soft tissue | Subcutaneous angiosarcoma | 1 (1%) | 788 | — | | | Hemangioendothelioma | 1 (1%) | 414 | 2 (3%) | 497 ± 103.1 | | Skin | Squamous-cell carcinoma | — | — | 1 (1%) | 392 | | Colon | Adenocarcinoma | — | | 1 (1%) | 393 |
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Significant in comparison with the PARP-1+/+:*: ;**: ;***: .
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