Research Article
Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice
Table 8
Effects of PARP-1 knockout in female mice.
| | Parameter | PARP-1−/− versus PARP-1+/+ | Comment |
| | Body weight | Increased after the
age of 21 months | Accelerated aging | | Food consumption | No difference | No effect | | Body temperature | Increased | Accelerated aging | | Maturation (vagina
opening) | accelerated | Accelerated
maturation | | Estrous function | Rate of mice with
irregular cycles increased | Accelerated aging |
| | Locomotor activity | |
Young −/− mice more
active, but more physically weak than
+/+ mice; accelerated aging | | No. of crossed squares | Increased | | No. of vertical racks | Increased | | Duration of standing
reaction | Decreased | | Duration of the 1st and 2nd suspension time | Decreased |
| | Biochemical parameters | | | | Total protein | Decreased with age |
Accelerated aging | | Uric acid | Decreased at the age
of 20 months | | Calcium level | Decreased at the age
of 4 months | Prone to
osteoporosis | | Alanine
aminotransferase | No age-related
decrease |
Disturbance in the
age pattern | | Lactate
dehydrogenase | No age-related
decrease | | α-amylase | Decreased at the age
of 4 months | Accelerated aging | | Mean life span | Reduced | Accelerated aging | | Mean life span of
last 10% of survivors | Reduced | | Maximum life span | Reduced | | Aging rate | Increased | | MRDT | Reduced | | No. of malignant
tumor-bearing mice | Increased | Progression of
carcinogenesis | | Total number of
malignant tumors | Increased |
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