Age-Related Deficits in Spatial Memory and Hippocampal Spines in Virgin, Female Fischer 344 Rats

Figure 3

Spine density. Columns are the mean number of spines/10 μm of dendrite length ± SEM. Data analyzed by two-way ANOVA, group (young, aged) × field (CA1 apical, CA1 basal, CA3 apical, CA3 basal). A significant effect of field, 𝐹(3,60)=14.24,𝑃<0.000, and a significant group × field interaction, 𝐹(3,60)=3.35,𝑃<0.009, was found. Post hoc differences between young and aged fields were tested by t-test, *𝑃<0.049.