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Current Gerontology and Geriatrics Research
Volume 2011 (2011), Article ID 791765, 6 pages
http://dx.doi.org/10.1155/2011/791765
Research Article

Does the Serum Testosterone Level Have a Relation to Coronary Artery Disease in Elderly Men?

1Department of Internal Medicine, Specialized Medical Hospital, Faculty of Medicine, Mansoura University, B.O. Pox 35516, Al-Gomhoria Street, Mansoura, Egypt
2Department of Cardiology, Faculty of Medicine, Mansoura University, B.O. Pox 35516, Mansoura, Egypt
3Department of Clinical Pathology, Faculty of Medicine, Mansoura University, B.O. Pox 35516, Mansoura, Egypt

Received 4 January 2011; Revised 12 March 2011; Accepted 19 March 2011

Academic Editor: Fulvio Lauretani

Copyright © 2011 Mohamed A. Helaly et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The low serum level of testosterone in the elderly subjects may contribute to coronary artery disease (CAD). Our aim is to study serum levels of free testosterone in elderly men with CAD. Subjects and Methods. This study was conducted on 100 elderly males with CAD, one half of them was presented with ACS (with mean age 6 9 . 6 ± 2 . 4 4 year), and the other half was presented with stable CAD (with mean age 6 9 . 4 2 ± 2 . 1 4 year), in addition to 50 apparently healthy elderly males (with mean age 6 9 . 0 6 ± 1 . 6 4 year) as a control group. We detected the levels of serum free testosterone, cortisol, fibrinogen, plasminogen activator inhibitor-1(PAI-1), high sensitive C-reactive protein(hsCRP), interleukin-6(IL-6). Results. Cases with CAD had significant lower values of free testosterone and HDL-c, but they had significant higher values of cortisol, fibrinogen, PAI-1, IL-6, hsCRP, in comparison to control group. Cases with ACS had significant higher values of cortisol, hsCRP, IL-6, fibrinogen, PAI-1, total cholesterol and BMI more than those with stable CAD. The free testosterone had significant negative correlation with fibrinogen, PAI-1, hsCRP and IL-6 in both groups of patients. Conclusion. The lower value of serum free testosterone in elderly male subjects may contribute to CAD.