Review Article
Mechanisms and Implications of Age-Related Changes in the Liver: Nonalcoholic Fatty Liver Disease in the Elderly
Table 1
Disease progression in NAFLD/NASH and risk factors predicting disease progression [
53–
56].
| | Powell et al. 1990 [53] | Harrison et al. 2003 [54] | Fassio et al. 2004 [55] | Adams et al. 2005 [56] |
| Number of patients with serial liver biopsy | 13 | 22 | 22 | 103 | Age (years) | 49 (16–70) | 50.6 (33–64) | 45 (20–69) | 45 (19–65) | Biopsy interval (years) | 1–9 | N/A | 1–3 | 0.7–21 | Follow-up period (years) | 1.5–21.5 | 1.4–15.7 | 3–14.3 | N/A | Disease activity (%) | | | | | Unchanged | 46% | 50% | 68% | 34% | Progress | 30% | 32% | 31.8% | 37% | Regress | 23% | 18% | 0% | 29% | Risk factors associated with NASH progression | None identified | AST | Obesity | Obesity | | | BMI | BMI | | | | Low initial fibrosis score |
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N/A: not available; AST: aspartate transaminase.
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