Review Article
Mechanisms and Implications of Age-Related Changes in the Liver: Nonalcoholic Fatty Liver Disease in the Elderly
Table 2
Natural history data on NAFLD.
| | Adams et al. 2005 [57] | Ekstedt et al. 2006 [75] | Ong et al. 2008 [76] | Rafiq et al. 2009 [77] | | NAFLD | NASH | NNFL | NAFLD | NASH | NNFL |
| | N | 435 | 71 | 58 | 817 | 72 | 101 | | Age at diagnosis (in years) | | | | | | | | Males/females | 213/222 | | | | 30/70 | 47/53 | | Study period | 1980–2000 | 1988–1993 | | 1988–1994 | 1979–1987 | | | Followup (in years) | | | | 8.4 (median) | 10.5 (median) | 13.0 (median) | | Advanced cirrhosis | 13 (3.1%) | 7 (9.8%) | 0 | | | | | HCC | 2 (0.5%) | 2 (2.8%) | 0 | | | | | Deaths (total) | 53 (12.1%) | 26 (20.3%) | | 80 (9.7%) | | | | IHD | 13 (2.9%) | 11 (15.5%) | 5 (8.6%) | 20 (2.4%) | 7 (12.3%) | 15 (20.3%) | | Non-HCC cancer | 15 (3.4%) | 4 (5.6%) | 1 (1.7%) | 19 (2.3%) | 5 (8.8%) | 9 (12.2%) | | Liver* | 7 (1.6%) | 2 (2.8%) | 0 | 5 (0.6%) | 10 (17.5%) | 2 (2.7%) |
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NNLF: non-NASH fatty liver (which equates with simple steatosis referred to in the text); *liver related mortality.
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