Current Gerontology and Geriatrics Research / 2012 / Article / Tab 3 / Research Article
Sterol Lipid Metabolism in Down Syndrome Revisited: Down Syndrome Is Associated with a Selective Reduction in Serum Brassicasterol Levels Table 3 Serum analytes in control and DS cohorts by age. Analytes shown in bold are significantly different between control and DS groups by unpaired student’s
-test. Welch’s correction was applied when variances were significantly different between groups.
Con < 45 DS < 45
Con > 45 DS > 45
TC (mmol/L) 4.859 (±0.622) 5.095 (±1.050) 0.576 4.974 (±0.793) 4.811 (±1.201) 0.727 HDL-C (mmol/L) 1.632 (±0.632) 1.357 (±0.293) 0.340 1.643 (±0.410) 1.443 (±0.268) 0.204 ApoA-I (mg/mL) 1.447 (±0.298) 1.333 (±0.179) 0.362 1.547 (
±
0.196) 1.317 (
±
0.188) 0.016 ApoB (mg/mL) 0.826 (±0.196) 0.918 (±0.203) 0.358 0.780 (±0.162) 0.891 (±0.293) 0.320 CRP (mmol/L) 0.800 (±1.872) 2.743 (±2.045) 0.051 1.233 (±1.806) 2.938 (±2.286) 0.107 Campesterol (mg/dL) 0.5406 (±0.333) 0.4378 (±0.283) 0.547 0.4894 (
±
0.219) 0.3015 (
±
0.114) 0.014 Sitosterol (mg/dL) 0.437 (±0.238) 0.352 (±0.225) 0.506 0.422 (
±
0.213) 0.2369 (
±
0.102) 0.010 24S-OH cholesterol 63.67 (±3.122) 66.50 (±15.20) 0.721 60.78 (±3.172) 71.36 (±7.038) 0.187 Lathosterol (mg/dL) 0.2039 (±0.115) 0.2703 (±0.092) 0.259 0.1951 (±0.085) 0.2054 (±0.141) 0.847 Campestanol (mg/dL) 3.639 (±1.704) 4.138 (±2.789) 0.672 3.659 (±0.990) 3.038 (±1.187) 0.207 Stigmasterol (mg/dL) 10.09 (±1.092) 13.99 (±3.103) 0.280 10.33 (±1.996) 11.04 (±3.360) 0.572 Sitostanol (mg/dL) 4.709 (±1.394) 5.338 (±3.018) 0.591 4.790 (±1.106) 3.921 (±1.183) 0.084 Lanosterol (mg/dL) 20.11 (±11.26) 21.80 (±10.60) 0.776 18.60 (±10.15) 20.81 (±11.79) 0.648 Dihydrolanosterol (mg/dL) 13.66 (±2.625) 14.25 (±4.562) 0.739 13.60 (±3.067) 14.81 (±4.473) 0.487 Desmosterol (mg/dL) 0.1522 (±0.063) 0.1413 (±0.058) 0.741 0.1352 (±0.047) 0.1244 (±0.073) 0.696 7
-OH-cholesterol (ng/mL) 86.89 (±47.13) 81.67 (±1.60) 0.919 57.78 (±34.59) 106.4 (±97.33) 0.167 Cholesterol (mg/dL) 178.8 (
±
22.16) 222.2 (
±
32.25) 0.008 192.3 (±30.57) 203.8 (±53.01) 0.564 27-OH cholesterol (ng/mL) 219.1 (
±
57.88) 135.0 (
±
44.99) 0.010 164.8 (±46.98) 135.0 (±46.27) 0.149 Cholestanol (mg/dL) 0.2743 (
±
0.070) 0.3727 (
±
0.085) 0.022 0.2976 (±0.059) 0.3404 (±0.091) 0.274 Brassicasterol (mg/dL) 35.40 (
±
17.83) 14.12 (
±
10.90) 0.039 33.07 (
±
19.02) 9.886 (
±
3.99) 0.007
