Nicotinamide, NAD(P)(H), and Methyl-Group Homeostasis Evolved and Became a Determinant of Ageing Diseases: Hypotheses and Lessons from Pellagra

Table 1

Three worlds that interact are largely human thermodynamic and cognitive niche constructions that are all heritable making us codirectors of our own and our collaborators evolution. There is a cost to this cumulative evolution that may include hypo- and hypervitaminosis, energy, and informatic states.

Thermodynamic and material	Personal	Information and society
Omnivorous diet	Conscious perception	Divisions of labour
Trading symbionts	Empathy	Trading
Shelter/clothes	Mental time travel	Information stores
	Know-how
	Language
	Nutrigenomics
	Immunogenomics
	Neuro/endocrine homeostasis

Surplus energy for innovation of tools and technology and further harnessing of energy.