The Role of Insulin and Insulin-Like Growth Factor-1/FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia

<table>Function and targets genes of FoxO transcription factors. Abbreviations: IR, insulin receptor; PGC1, peroxisome-proliferative-activated receptor-<i>γ</i> (PPAR<i>γ</i>) coactivator 1; BIM, Bcl2-interacting mediator of cell death; p21, cyclin-dependent kinase inhibitor 1 (review in [<a href="../#B151">58</a>]).</table>

Current Gerontology and Geriatrics Research

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Figure 2

Figure 2: The Role of Insulin and Insulin-Like Growth Factor-1/FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia 