Intraindividual Variability in Domain-Specific Cognition and Risk of Mild Cognitive Impairment and Dementia

Table 2

Hazard ratios for the cognitive domains (alone and controlling for all other cognitive domains) predicting MCI, probable dementia, and MCI or probable dementia.

Cognitive domains	MCI (𝑁=74)			Probable dementia (𝑁=45)			MCI or probable dementia (𝑁=101)
	HR	95% CI	𝑃 value	HR	95% CI	𝑃 value	HR	95% CI	𝑃 value
Vocabulary alone	0.58	[0.46, 0.73]	<0.0001	0.46	[0.34, 0.62]	<0.0001	0.53	[0.44, 0.65]	<0.0001
Verbal fluency alone	0.49	[0.37, 0.65]	<0.0001	0.53	[0.37, 0.74]	0.0003	0.52	[0.41, 0.66]	<0.0001
Figural memory alone	0.49	[0.40, 0.61]	<0.0001	0.39	[0.30, 0.51]	<0.0001	0.46	[0.38, 0.55]	<0.0001
Verbal memory alone	0.27	[0.21, 0.35]	<0.0001	0.22	[0.16, 0.31]	<0.0001	0.29	[0.23, 0.36]	<0.0001
Attention/Working memory alone	0.63	[0.48, 0.81]	0.0005	0.61	[0.44, 0.85]	0.0039	0.60	[0.48, 0.75]	<0.0001
Spatial ability alone	0.60	[0.45, 0.79]	0.0003	0.36	[0.24, 0.53]	<0.0001	0.52	[0.40, 0.66]	<0.0001
Fine motor speed alone	0.79	[0.64, 0.98]	0.0306	0.91	[0.69, 1.20]	0.4962	0.79	[0.66, 0.95]	0.0113
Vocabulary | others	0.91	[0.69, 1.18]	0.4655	0.70	[0.49, 1.00]	0.0486	0.82	[0.65, 1.04]	0.0955
Verbal fluency | others	0.87	[0.65, 1.17]	0.3608	1.39	[0.95, 2.03]	0.0899	1.00	[0.78, 1.29]	0.9967
Figural memory | others	0.74	[0.58, 0.95]	0.0186	0.68	[0.50, 0.92]	0.0119	0.71	[0.57, 0.87]	0.0014
Verbal memory | others	0.32	[0.24, 0.42]	<0.0001	0.26	[0.17, 0.39]	<0.0001	0.34	[0.27, 0.44]	<0.0001
Attention/Working memory | others	0.95	[0.70, 1.28]	0.7260	0.99	[0.66, 1.47]	0.9555	0.94	[0.72, 1.22]	0.6186
Spatial ability | others	0.91	[0.67, 1.23]	0.5267	0.66	[0.43, 1.02]	0.0639	0.84	[0.64, 1.10]	0.2003
Fine motor speed | others	0.83	[0.66, 1.04]	0.1039	0.86	[0.63, 1.18]	0.3436	0.83	[0.68, 1.00]	0.0549