Table 3: Hazard ratios for IAV Cognitive Domains and IAV time (alone and controlling for baseline and slope overall cognition, EF, and verbal episodic memory) predicting MCI, probable dementia, and MCI or probable dementia.

ParameterMCI ( )Probable dementia ( )MCI or probable dementia ( )
HR95% CI valueHR95% CI valueHR95% CI value

Overall cognition0.32[0.25, 0.41]<0.00010.25[0.18, 0.35]<0.00010.30[0.24, 0.37]<0.0001
EF0.48[0.37, 0.63]<0.00010.50[0.35, 0.70]<0.00010.48[0.38, 0.61]<0.0001
Verbal episodic memory0.27[0.21, 0.35]<0.00010.22[0.16, 0.31]<0.00010.29[0.23, 0.36]<0.0001
Standard deviation (SD)
(IAV Cognitive Domains)
1.07[0.44, 2.59]0.88914.72[1.76, 12.7]0.00211.71[0.82, 3.55]0.1525
SD overall cognition1.09[0.44, 2.71]0.85344.15[1.56, 11.0]0.00431.72[0.82, 3.61]0.1543
SD EF1.23[0.50, 3.03]0.65966.46[2.37, 17.6]0.00032.06[0.98, 4.34]0.0567
SD verbal episodic memory0.45[0.18, 1.12]0.08652.19[0.71, 6.73]0.17270.77[0.36, 1.66]0.5011
Slope standard deviation (SD)
(IAV Time)
3.13[2.05, 4.78]<0.00013.80[2.23, 6.46]<0.00013.05[2.13, 4.36]<0.0001
Slope SD overall cognition2.99[1.98, 4.51]<0.00013.96[2.37, 6.61]<0.00013.10[2.18, 4.41]<0.0001
Slope SD EF3.03[2.04, 4.52]<0.00014.27[2.45, 7.43]<0.00013.07[2.17, 4.34]<0.0001
Slope SD verbal episodic memory3.27[2.14, 5.00]<0.00014.87[2.83, 8.38]<0.00013.35[2.35, 4.78]<0.0001
Slope SD overall cognition, overall slope2.34[1.65, 3.31]<0.00012.26[1.51, 3.38]<0.00012.07[1.53, 2.80]<0.0001
Slope SD EF, EF slope3.05[2.04, 4.57]<0.00013.76[2.37, 5.96]<0.00012.89[2.11, 3.97]<0.0001
Slope SD verbal episodic memory, verbal episodic memory slope2.05[1.34, 3.15]0.00101.50[1.01, 2.23]0.04331.58[1.16, 2.16]0.0039
Slope SD SD, overall cognition, EF, verbal episodic memory, overall slope, EF slope, verbal episodic memory slope2.32[1.46, 3.69]0.00041.46[0.84, 2.55]0.18421.70[1.16, 2.49]0.0061