About this Journal Submit a Manuscript Table of Contents
Current Gerontology and Geriatrics Research
Volume 2013 (2013), Article ID 986254, 5 pages
http://dx.doi.org/10.1155/2013/986254
Research Article

Assessment of Platelet Indices in Patients with Neurodegenerative Diseases: Mean Platelet Volume Was Increased in Patients with Parkinson’s Disease

1Medical Faculty, Istanbul Medeniyet University, Istanbul, Turkey
2Düzce University, Düzce, Turkey
3Bezmialem Vakıf University, Istanbul, Turkey

Received 18 July 2013; Revised 10 November 2013; Accepted 11 November 2013

Academic Editor: Hiroyuki Umegaki

Copyright © 2013 Abdulkadir Koçer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Platelets induce chronic inflammation which is a key step in atherosclerosis and may be involved in the progression of neurodegenerative diseases (NDD). We aimed to measure the mean platelet volume (MPV) and platelet count (PLC) in NDD patients. The present study was designed to investigate the platelet function by measuring MPV and PLC in NDD. A total of 182 outpatients with Alzheimer’s (AD) or Parkinson’s diseases (PD) were included. The control group consisted of 104 healthy subjects. Platelet count was similar between groups. MPV values of PD patients were higher than those of AD patients and controls ( ). MPV correlated negatively with Heohn and Yahr scale (HYS) score ( ). Increased MPV in patients with PD may point to a platelet dysfunction. High-grade inflammation presents with low levels of MPV as seen in PD patients with high HYS scores.