Nutrition and Dementia

Call for Papers

Dementia is a progressive decline in the ability to remember, learn, understand, and communicate. Alzheimer's disease represents the most common form of dementia in the elderly, affecting about 28 million individuals worldwide. Current treatments for Alzheimer's disease and other dementias are sorely limited, falling short of preventing or significantly slowing disease progression. Compelling epidemiological observations suggest that human nutrition and lifestyle factors can modify the risk of late onset dementia. This has motivated fundamental research to clarify the underlying pathophysiological mechanisms and clinical research into the efficacy of the indicated interventions. Despite this, evidence for the cognitive benefit of nutritional and lifestyle interventions in Alzheimer's disease remains equivocal, and a clear elucidation of mechanisms remains elusive. This special issue aims to present cutting-edge basic and clinical research on nutrition in dementia and to provide a timely forum for the critical evaluation and delineation of new approaches and opportunities for nutritional and lifestyle interventions.

We invite investigators to contribute original research articles, review articles, and meta-analyses of the literature that will stimulate the continuing efforts to understand the possible contribution of dietary factors in late onset dementia. Potential topics include, but are not limited to:

• Vitamins, micronutrients, and dementia
• Early life nutrition and risk of late onset dementia
• Role of Mediterranean diet, antioxidants, omega-3 fatty acids, and food bioactive compounds
• One carbon metabolism, epigenetics, and dementia risk and prevention
• Food combinations and nutritional strategies for the prevention of cognitive decline
• Nutrigenomic and metabolic determinants of dementia risk
• Obesity, insulin, metabolic syndrome, and dementia risk
• Nutrient sensing and brain metabolism in brain aging
• Special design considerations for nutrition intervention trials in dementia
• Role of caregivers in supporting dementia patients and treatment of nutrition problems with PEGs
• Evidence-based medicine, closing the gaps between basic, epidemiologic, and clinical research

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/cggr/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:

Lead Guest Editor

• Fabio Coppede, Faculty of Medicine, Section of Medical Genetics, University of Pisa, Via S. Giuseppe 22, 56126 Pisa, Italy

Guest Editors

• Paolo Bosco, IRCCS, Oasi Maria SS Institute for Research on Mental Retardation and Brain Aging, Via Conte Ruggero 73, 94018 Troina (EN), Italy
• Andrea Fuso, Department of Psychology and Department of Surgery “P. Valdoni”, Sapienza University of Rome, 00185 Rome, Italy
• Aron Troen, Nutrition and Brain Health Laboratory, Institute of Biochemistry, Food Science and Nutrition, the Hebrew University of Jerusalem, Jerusalem 91904, Israel